Adelaide Fernandes

Central Nervous System, Blood and Peripheral Inflammation

Our lab focuses on the role of inflammation in the emergence or progression of neurodevelopmental and neurodegenerative disorders. We are particularly interested in the interplay between the Central Nervous System (CNS)-centered neuroinflammation and the inflammatory response derived from the periphery.

Modulation of neuroinflammation to ameliorate Multiple Sclerosis pathogenesis

Focus on the modulation of CNS inflammation by tackling both glial reactivity and immune system response in order to reduce damage and improve recovery during demyelinating insults as Multiple Sclerosis.

Assessment of Frailty in Multiple Sclerosis to better monitor disease phenotype

We developed a new method to determine the Frailty index associated with Multiple Sclerosis pathogenesis that may be used in the monitoring of both disease animal models and Multiple Sclerosis patients. We are now focusing on how this frailty index may relate to age, immune cell response and microbiota.

Role of microglia in synaptic pruning during demyelination and association with cognitive impairment

Our major goal is to unveil the mechanisms underlying microglia-T cell interplay that may justify synaptic pruning during demyelination and how this may be related to Multiple Sclerosis-associated cognitive impairment.

Imaging of myelin debris and microglia clearance using BASHY dyes

We are focusing on the use of the BASHY platform to image myelin debris clearance by microglia at the CNS following demyelination.

Santos G, Barateiro A, Brites D, Fernandes A. S100B impairs oligodendrogenesis and myelin repair following demyelination through RAGE engagement. Front Cell Neurosci. 2020; 14:279. DOI: 10.3389/fncel.2020.00279
Mahú I, Barateiro A, Rial-Pensado E, Martinéz-Sánchez N, Vaz SH, Cal PMSD, Jenkins B, Rodrigues T, Cordeiro C, Costa MF, Mendes R, Seixas E, Pereira MMA, Kubasova N, Gres V, Morris I, Temporão C, Olivares M, Sanz Y, Koulman A, Corzana F, Sebastião AM, López M, Bernardes GJL, Domingos AI. Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects. Cell Metab. 2020; 31(6):1120-1135.e7. DOI: 10.1016/j.cmet.2020.04.013
das Neves SP, Santos G, Barros C, Pereira DR, Ferreira R, Mota C, Monteiro S, Fernandes A, Marques F, Cerqueira JJ. Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms. J Neuroimmunol. 2020; 340:577163. DOI: 10.1016/j.jneuroim.2020.577163. Epub 2020 Jan 13
Bellantuono, I (and 12 signatories including Fernandes A). Find drugs that delay many diseases of old age. Nature (Commentary) 2018; 554:293-295. DOI: 10.1038/d41586-018-01668-0
Santos G, Barateiro A, Gomes CM, Brites D, Fernandes A. Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment. Neuropharmacology. 2018; 129:69-83. DOI: 10.1016/j.neuropharm.2017.11.002

Adelaide Fernandes

Group Leader


Phone: (+351) 217946400 (Ext. 14527)

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Faculdade de Farmácia da Universidade de Lisboa | Av. Professor Gama Pinto
1649-003 Lisboa | Portugal

Phone | +351 217 946 400
Fax | +351 217 946 470
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