Our lab focuses on the role of inflammation in the emergence or progression of neurodevelopmental and neurodegenerative disorders. We are particularly interested in the interplay between the Central Nervous System (CNS)-centered neuroinflammation and the inflammatory response derived from the periphery.
Modulation of neuroinflammation to ameliorate Multiple Sclerosis pathogenesis
Focus on the modulation of CNS inflammation by tackling both glial reactivity and immune system response in order to reduce damage and improve recovery during demyelinating insults as Multiple Sclerosis.
Assessment of Frailty in Multiple Sclerosis to better monitor disease phenotype
We developed a new method to determine the Frailty index associated with Multiple Sclerosis pathogenesis that may be used in the monitoring of both disease animal models and Multiple Sclerosis patients. We are now focusing on how this frailty index may relate to age, immune cell response and microbiota.
Role of microglia in synaptic pruning during demyelination and association with cognitive impairment
Our major goal is to unveil the mechanisms underlying microglia-T cell interplay that may justify synaptic pruning during demyelination and how this may be related to Multiple Sclerosis-associated cognitive impairment.
Imaging of myelin debris and microglia clearance using BASHY dyes
We are focusing on the use of the BASHY platform to image myelin debris clearance by microglia at the CNS following demyelination.
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