The Bioorganic Chemistry laboratory is focused on the interface of organic chemistry and biology, aiming at the discovery and process intensification of new more sustainable synthetic methodologies that, in collaboration with biomedical laboratories, can be further explored to tackle important biological problems related with infectious diseases, oncology and inflammation.
This synthetic organic chemistry laboratory is focus on the following research areas: Development of bio-inspired, efficient (non)catalyzed and sustainable synthetic methodologies, for the synthesis of complex/target molecules; Total synthesis of biologically active and chemically useful small molecules, based on the isolation/synthesis and chemical/biotechnology valorisation of natural resources; Process intensification via flow chemistry, including photocatalysis, high pressure and electrosynthesis.
Taking advantage of the novel synthetic methodologies developed within our group, diverse families of small molecules are screened for anticancer activity aiming at the identification of new scaffolds.
We are focused on identifying lead compounds as necroptosis inhibitor derived from our structurally diverse synthesized molecules.
The diversity of small molecules synthetized in our lab allows identification of new anti-bacterial and anti-malarial scaffolds.