João Almeida Lopes

Pharmaceutical Engineering and Manufacturing

The PhEMLab is focused on the underpinning sciences related with the design, optimization and manufacturing of bulk pharmaceutical dosage forms. The PhEmLab is oriented for pharmaceutical materials characterization (solid-state), particle engineering, drug products manufacturing process development (including continuous and 3D printing), modelling and advanced real-time high-throughput monitoring. The PhEMLab operates in strong collaboration with the pharmaceutical industry.

The Pharmaceutical Engineering and Manufacturing Lab (PhEMLab) dedicates to all aspects concerning the materials characterization, drug products development and manufacturing processes development. The lab is focused on underlying material sciences (focus on solid state physics), use of novel excipients, emerging manufacturing technologies (such as continuous manufacturing or additive manufacturing) and processes modelling and simulation, all directed towards translational activities. Activities range from formulation development, advanced process development and real-time control of manufacturing processes (PAT) up to the areas of personalized medicines (e.g., 3D printing technologies). The lab encompasses a strong interaction with the pharmaceutical industry at the National and European levels and a wider network of scientific collaborations worldwide in the fields of particle engineering and process analytical technology, as demonstrated by the high number of PhD students carrying out their scientific projects abroad. Strong and effective support to industry is provided by the lab in all areas related with drug products manufacturing processes with focus on solid bulk drug products. Additionally, PhEMLab members sit on multiple national and pan-European organizations directive boards related to the pharmaceutical sciences.

Macedo J, Samaro A, Vanhoorne V, Vervaet C, Pinto JF. Processability of poly(vinyl alcohol) based filaments with paracetamol prepared by hot-melt extrusion for additive manufacturing. J Pharm Sci 2020; 109: 3636-3644. DOI: 10.1016/j.xphs.2020.09.016
Costa NF, Fernandes AI, Pinto JF. Measurement of the amorphous fraction of olanzapine incorporated in a co-amorphous formulation. Int J Pharm 2020; 588:119716. DOI: 10.1016/j.ijpharm.2020.119716
Nese C, Palugan L, Cerea M, Pinto JF. Preparation and characterization of a powder manufactured by spray drying milk based formulations for the delivery of theophylline for pediatric use. Int J Pharm 2020; 580:119227. DOI: 10.1016/j.ijpharm.2020.119227
Silva AFT, Sarraguça MC, Fonteyne M, Vercruysse J, de Leersnyder F, Vanhoorne V, Bostijn N, Verstraeten M, Vervaet C, Remon JP, de Beer T, Lopes JA. Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process. Int J Pharm 2017; 528: 242-252. DOI:10.1016/j.ijpharm.2017.05.075
Silva AFT, Sarraguça MC, Ribeiro PR, de Beer T, Lopes JA. Statistical process control of cocrystallization processes: A comparison between OPLS and PLS. Int J Pharm 2017; 520: 29-38. DOI:10.1016/j.ijpharm.2017.01.052

João Almeida Lopes

Group Leader

Email: jlopes@ff.ulisboa.pt

Phone: (+351) 217946434 (Ext. 14377)

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Faculdade de Farmácia da Universidade de Lisboa | Av. Professor Gama Pinto
1649-003 Lisboa | Portugal


Phone | +351 217 946 400
Fax | +351 217 946 470
Web | www.imed.ulisboa.pt
Email | imed.ulisboa@ff.ulisboa.pt

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