Our lab is focused on genomic studies based on genome sequencing and application of computational and bioinformatics approaches, as well as computation-driven experimental approaches, to comprehend the evolution, epidemiology, virulence, population level genomic variation and phylogeography of pathogens.
Genomics and evolution of H. pylori
The human gastric carcinogen Helicobacter pylori infects half the world’s population. We are interested in describing the worldwide genomic and epigenomic variation of H. pylori to identify molecular determinants of carcinogenicity, virulence, antibiotic resistance and phylogeography.
Prophages and genome dynamics
Bacteriophages (phages) specifically infect and eliminate bacteria. There are about 10E31 phages in the planet, but <1% are estimated to be described. We aim to characterize prophages of gut bacteria and to disclose prophage role in the fitness and pathogenicity of H. pylori.
Phage lysin therapy
Use of a computer driven approach to identify prophages in bacteria and their lytic enzymes, which, in combination with an experimental biotechnological approach aims to produce enzybiotics (phage lysin therapy) against antibiotic resistant bacteria declared by the World Health Organization as a priority to develop novel antibiotics.
Bioinformatics and Computational Biology
Additionally, we aim to develop bioinformatics tools for efficient big data analysis, cooperate and provide services to other in-house and foreign groups.