Margarida Castro-Caldas

Principal Investigator
Short bio & current area(s) of interest
Margarida Castro-Caldas is an Assistant Professor at FCT NOVA, PI at iMed.ULisboa, and collaborator at the Glycoimmunology group from UCIBIO (FCT NOVA). She graduated in Biology in University of Lisbon, did a post-graduation in Cell Biology at University of Coimbra in 1999, and obtained her PhD in Cell Biology in 2004 at University of Coimbra. In 2004, she received a post-doctoral grant from FCT to start a new project at Faculty of Pharmacy, related to the neurodegeneration mechanisms in Parkinson’s disease. Margarida has been awarded with several grants from FCT, Ciência Viva and Dana Foundation for Brain Initiatives and FENS, and has been participating in several scientific projects, always within the scope of Biomedicine and with high translational application in areas from cardiac to rheumatological and neurodegenerative diseases. Margarida’s main goal is to discover new therapeutic targets and neuroprotective approaches for neurodegenerative disorders, namely Parkinson’s disease. Her focus has been the characterization of the neuroprotective effects of the bile acid TUDCA in Parkinson’s disease. Moreover, she has been focusing on the cellular and molecular mechanisms underlying neurodegeneration, including post-translational modifications of proteins by glycosylation, the redox state and mitochondrial function, quality control pathways, and neuroinflammation to identify new putative therapeutic strategies to afford neuroprotection in Parkinson’s disease. Margarida is also actively involved in the coordination of several initiatives in the scope of the International Brain Awareness Week, and several other initiatives that aim bridging the scientific community and the general public.

BSc (1995) in Biology, Universidade de Lisboa, Lisbon, Portugal

PhD (2004) in Cell Biology, Universidade de Coimbra, Coimbra, Portugal

Postdoctoral Fellow (2004-2006), Universidade de Lisboa, Lisbon, Portugal

Assistant Professor, NOVA School of Science and Technology, NOVA University of Lisbon, Caparica, Portugal

Principal Investigator, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal

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