Constantino’s research interests are the study of xenobiotic metabolism and the development of new drug delivery systems. His PhD was in the mechanism of amide metabolism by CYP 450 and later he studied drug metabolism. From that he got interested in prodrugs, specifically in their activation by metabolic reactions and in the prevention of prodrug inactivation. Currently he is studying ester prodrugs for the treatment of tuberculosis and development of new drugs to treat tuberculosis. He is also an expert in patents in the area of pharmacy and has a deep interest in innovation and entrepreneurship.