João Gonçalves

Group Leader
Short bio & current area(s) of interest
The laboratory is interested on biomolecular and biopharmaceutical engineering aiming the investigation, analysis, and integration of genomic and proteomic data towards the design of therapeutic proteins. This will lead us to guide protein engineering through molecular medicine and bio-nanotechnology in a mid- to long-term timeframe. At the center of our biopharmaceutical development we aim at rational antibody engineering as our approach to validate our theoretical concepts. We consider the use of intracellular and extracellular small-domain antibodies to be exemplary in our rational protein engineering strategies. The interest in protein therapeutics may stem the discovery and development of new leads for biopharmaceuticals in the area of infectious diseases, cancer and neurological problems. The focus on the discovery and development of a new class of therapeutic antibodies and efficient display technologies may allow the rapid identification of binding proteins with high affinity and specificity. In addition , we plan to adapt our antibody domain platform and synthetic biology approaches to develop CAR-T receptors based on SynNotch engineered cells that may have even broader applications as general delivery agents that can locally produce any genetically encoded bio-therapeutic that has systemic toxicity. Development of better characterization assays and monitoring of antibody therapy in patients, including immunogenicity and pharmacokinetics to biosimilars is current to our work. The evaluation of quality, efficacy and safety attributes of biosimilar antibodies and fusion proteins is at the centre of our clinical collaborations.

BSc (1991) in Faculty of Pharmacy, University of Lisbon, Lisboa, Portugal

PhD (1996) in Faculty of Pharmacy, University of Lisbon, Lisboa, Portugal

Research Assistant (1992-1996), Dana Farber Cancer Institute, Dana-Farber cancer Institute, Harvard University, Boston, USA

Post-doctoral Fellow (1999-2000), Scripps Research Institute, San Diego, USA.

Full Professor, Faculty of Pharmacy, University of Lisbon, Lisboa, Portugal

Group Leader, iMed, Faculty of Pharmacy, University of Lisbon, Lisboa, Portugal

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Faculdade de Farmácia da Universidade de Lisboa | Av. Professor Gama Pinto
1649-003 Lisboa | Portugal

Phone | +351 217 946 400
Fax | +351 217 946 470
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