André L. Simão scientific career started in 2012 when he had the opportunity to participate, as a Pharmaceutical Sciences Master student, in a research project at iMed.ULisboa aiming to decipher the role of microRNAs in modulating apoptosis- and necroptosis-related pathways during liver disease pathogenesis. Between 2015 and 2019, he developed his PhD studies under supervision of Dr. Rui Castro and Prof. Cecília Rodrigues, focusing on the role of mitochondria-targeting microRNAs in non-alcoholic fatty liver disease pathogenesis and on the potential therapeutic effects resulting from their modulation, in both liver and skeletal muscle. Currently, he is investigating whether exosome-associated microRNAs contribute to adipose tissue-to-liver communication and if they may constitute novel non-invasive biomarkers in metabolic diseases.