PhD (2005) in Pharmacy (Biochemistry), Universidade de Lisboa
Assistant Professor, Biochemistry and Human Biology, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Susana Solá is a major driving force guiding her laboratory stem cell studies. Based on a solid background on the molecular mechanisms that control cell fate decisions and her most recent discoveries in the stem cell field, she has been dedicated to further understanding and actively identifying potential check points and promising molecules that increase neural stem cell pool and neural differentiation as an alternative of cell death. Recently, she has also become interested in exploring the relevance of mitochondrial metabolism in interorgan communication to ultimately improve neuroplasticity and neurogenesis in adulthood and ageing.
Soares R, Ribeiro FF, Xapelli S, Genebra T, Ribeiro MF, Sebastião AM, Rodrigues CMP, Solá S. Tauroursodeoxycholic acid enhances mitochondrial biogenesis, neural stem cell pool, and early neurogenesis in adult rats. Mol Neurobiol 2018; 55: 3725-38.
Morgado AL, Rodrigues CMP, Solá S. MicroRNA-145 regulates neural stem cell differentiation through the Sox2–Lin28/let-7 signaling pathway. Stem Cells 2016; 34: 1386-95.
Xavier JM, Morgado AL, Solá S*, Rodrigues CMP*. Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress. Antioxid Redox Signal 2014; 21: 1009-24. *Equally contributed as senior author and corresponding author
Solá S, Amaral JD, Castro RE, Ramalho RM, Borralho PM, Kren BT, Tanaka H, Steer CJ, Rodrigues CMP. Nuclear translocation of ursodeoxycholic acid via the glucocorticoid receptor is essential for inhibiting TGF-1-induced apoptosis of rat hepatocytes. Hepatology 2005; 42: 925-934.
Rodrigues CMP, Solá S, Nan Z, Castro RE, Ribeiro PS, Low WC, Steer CJ. Tauroursodeoxycholic acid reduces apoptosis and protects against neurologic injury after acute hemorrhagic stroke in rats. Proc Natl Acad Sci USA 2003; 100: 6087-92.