Animal Facility

The Animal Facility supports the discovery and development of innovative medicines for the benefit of humans and animals. Animal experiments have been vital in pharmaceutical and biomedical research. Future advances in the treatment and diagnosis of human diseases will continue to depend on inquiries that use animals and other alternatives.

This is a conventional facility for the housing of laboratory rodents licensed by the National Authorities “Direção Geral de Alimentação e Veterinária” (DGAV). All animal experiments conducted in the Animal Facility are subject to rigorous review and must be previously submitted to the Animal Welfare Board (ORBEA – Orgão de Bem-Estar Animal) at the Faculty of Pharmacy, University of Lisbon (Regulamento 806/2016), and then approved by DGAV, the competent national authority responsible for implementing the legislation for the protection of animals for scientific purposes. Together, they ensure that research animals are used only when necessary and under humane conditions. Personnel and users are certified researchers for conducting animal experimentation and procedures are performed according to the EU Directive (2010/63/UE) and Portuguese laws (Decreto Lei 113/2013, Despacho 2880/2015 and Portaria 260/2016). iMed.ULisboa is committed to conducting the highest-quality research and to providing animals used in research with the best care available. Alternatives to animal use, which include computer modeling, cell culture and bacterial systems are often used at iMed.ULisboa.

The Animal Facility provides technical and scientific support to investigators on protocol development, refinement of experimental procedures, small surgery techniques, and services of husbandry and routine daily care (feeding, watering, and cage changing). Several animal models are established and under routine use in biodistribution and toxicity studies and disease modeling studies, including animal models of infection, acute and chronic inflammation, xenograft tumors, non-alcoholic fatty liver disease, neurodegenerative diseases. Upon request and contract, these or other animal models may be provided to external entities.

The Animal Facility consists of several rooms for animal maintenance with housing capacity of around 500 small rodents (rats and mice), and rooms for experimental procedures (small surgeries and dissections). Metabolic cages are also available. Support rooms are used for cleaning, washing and sterilization of cages and other equipment, food and bedding.

Head: Maria Manuela Gaspar