H2020 Societal Challenges – Health, demographic change and well-being


MADGIC proposes to generate human cellular models allowing for the purification of neural cell types involved in AD, which will be used to generate novel readouts. Patient neural cells generated by reprogramming technologies allow access to homogenous cultures, which grown alone or in mixed 3D cultures will be used to address disease relevant phenotypes both in vitro, and in vivo after transplantation into mouse models.

Funding ERA-NET-Cofund Transnational: Neurodegenerative Disease Research 2015
Call/Topic ERA-NET: Establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020
Title MADGIC: Generation of Improved cellular and animal models for identification of disease phenotype and new therapeutic targets of Alzheimer’s Disease
Start date January 2016
Duration 36 months
Project coordinator Jari Koistinaho, University of Eastern Finland, Finland
Project Partners Laurent Roybon, University of Lund, Sweden
Gunnar Gouras, University of Lund, Sweden
Claire Rampon, University of Toulouse, France
Dora Brites, iMed.ULisboa, Faculty of Pharmacy, University of Lisbon, Portugal
Michael T. Heneka, University Hospital of Bonn, Germany
Frank Edenhofer, University of Wurzburg, Germany
Tarja Malm, University of Eastern Finland, Finland