Nanostructured Systems for Overcoming Biological Barriers

Group Leader

António J. Almeida

PhD (1993) in Pharmaceutics, Aston University, Birmingham, UK.
Full Professor, Galenic Pharmacy and Pharmaceutical Technology, Faculdade de Farmácia, Universidade de Lisboa

The Research


Nanostructured Systems for Overcoming Biological Barriers 1

Overcoming biological barriers is the key for the development of many therapeutics and vaccines. Therefore, modulation of transport across biological barriers is one of the major challenges in the drug delivery field. Our group deals with complex and challenging problems involved in drug transport across biological barriers and delivery at cellular and intracellular target sites by means of engineering micro- and nanoformulation of bioactive entities. It aims at developing new drug delivery systems adequate for nanomedicine strategies in specific clinically relevant situations (inflammatory, infectious, genetic, autoimmune diseases and cancer) through a multidisciplinary approach involving existing competencies.

Nanostructured Systems for Overcoming Biological Barriers 2

Ongoing Projects

Source: FCT (PTDC/CTMNAN/2658/2014)
Title: Dual nanostructured lipid carriers as a multifunctional platform for brain tumor therapy
Team member: António J. Almeida
Period: 2016-2018

Source: FCT (PTDC/BBBBEP/2463/2014)
Title: ProbeCOPD. Protease activity based probes for chronic obstructive pulmonary disease diagnostics
Team member: Lídia M. Gonçalves
Period: 2016-2019

Source: COMPETE 2020
Title: POINT4PAC – Precision oncology by innovative therapies and technologies
Team Member: Sandra Simões
Period: 2017-2019

Source: Ministério da Defesa (CINAMIL 02_2018)
Title: LungShield – Medical Device for NBQR defence
Co-PI: António J. Almeida.
Period: 2018-2020.

Source: Programa Operacional Regional de Lisboa (LISBOA-01-0145-FEDER-030197)
Title: 3SLYCO – Sustainable, Safe, and Scalable (3S) approach for lycopene valorization: driving the knowledge toward an academia-industry interface for topical treatment of inflammation
PI: Sandra Simões
Period: 2018-2021.

Recent Most Relevant Publications

Marto J, Ruivo E, Lucas SD, Gonçalves LM, Simões S, Gouveia LM, Felix R, Moreira R, Ribeiro HM Almeida AJ. Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance. Eur J Pharm Biopharm 2018; 127: 1-11.

Mota AH, Rijo P, Molpeceres J, Reis CP. Broad overview of engineering of functional nanosystems for skin delivery. Int J Pharm 2017; 532: 710-728.

Gaspar DP, Gaspar MM, Eleutério C, Grenha A, Blanco M, Gonçalves LMD, Taboada P, Almeida AJ, Remuñán-López C. Microencapsulated solid lipid nanoparticles as a hybrid platform for pulmonary antibiotic delivery. Mol Pharmaceut 2017; 14: 2977-90.

Lopes RM, Pereira J, Esteves MA, Gaspar MM, Carvalheiro M, Eleutério CV, Gonçalves L, Jiménez-Ruiz A, Almeida AJ, Cruz ME. Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections. Nanomedicine-UK 2016; 11: 153-70.

Gaspar MM, Calado S, Pereira J, Ferronha H, Correia I, Castro H, Tomás AM, Cruz MEM. Targeted delivery of paromomycin in murine infectious diseases through association to nanolipid systems. Nanomed-Nanotechnol 2015; 11: 1851-60.




Group Members

PhD Students

  • Ana Luísa Mota
  • Ana Rebelo
  • Beatriz Rosa Silva
  • Catarina Garcia
  • Jacinta de Oliveira Pinho
  • Luís Roque
  • Sara Silva

Master Students

  • Ana Fernandes
  • Andreia Gonçalves
  • Angélica Graça
  • Lina Conceição
  • Maria Elena Spagli
  • Nuno Cruz
  • Patrícia Silva
  • Rodrigo Silva
  • Sara Bom


  • Carolina Chaves
  • Magda Ferreira
  • Paula Marques