Bioorganic Chemistry

Group Leader

Pedro M. P. Gois

PhD (2005) in Organic Chemistry, Universidade Nova de Lisboa
Post-Doctoral Fellow, Sussex University, University College of London, IST
Assistant Professor with habilitation, Pharmaceutical Chemistry and Therapeutics, Faculdade de Farmácia, Universidade de Lisboa

Other Principal Investigators: Carlos A. M. Afonso

The Research

Bioorganic Chemistry 1

The research conducted by the group Bioorganic Chemistry spans over the interface of organic chemistry and biology, aiming at the discovery of new generic synthetic methods and chemical probes that, in collaboration with biomedical scientists, may be further explored to tackle important biological problems related with infectious diseases, oncology and inflammation. Active research areas include:
Development of bio-inspired, efficient and sustainable synthetic methodologies for the preparation of small molecule modulators of enzymes and proteins identified as key therapeutic targets and cytotoxic agents;
Synthesis of biologically active and chemically useful small molecules, based on the isolation/synthesis and chemical/biotechnology valorisation of natural resources;
Synthesis of biologically active boron containing chemical probes and their evaluation as modulators of specific proteins;
The development of generic synthetic methods to modified proteins and their use in the synthesis of therapeutically useful bioconjugates.

Bioorganic Chemistry 2

Ongoing Projects

Source: FCT (PTDC/QEQ-QOR/1434/2014)
Title: BLink: Unravelling Boronic Acids Bioconjugation and Targeted Delivery
PI: Pedro M. P. Gois
Period: 2016-2019

Source: FCT (PTDC/QEQMED/5512/2014)
Title: Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer’s Disease
PI: Rudi Oliveira/Pedro M. P. Gois
Period: 2016-2019

Source: FCT (PTDC/QEQ-QOR/3644/2014)
Title: Stimulus responsive click chemistry: The first triggerable tetrazine ligation
PI: Alexandre Tindade/Carlos A. M. Afonso
Period: 2016-2019

Source: Marie Currie Innovative Training Networks – ITN
Title: ProteinConjugates
Deputy Coordinator: Pedro M. P. Gois
Period: 2015-2019

Source: European Research Area Network (ELAC2014/BEE-0341)
Title: Integrated valorization of lignocellulosic agroindustrial waste to furan based building blocks
PI: Carlos A. M. Afonso
Period: 2013-2015

Recent Most Relevant Publications

Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, Gois PMP. Modular Assembly of Reversible Multivalent Targeting Drug Conjugates. Angew Chem Int Ed 2017;  56: 9346-9350.

Faustino H, Silva MJSA, Veiros LF, Bernardes GJL, Gois PMP. Iminoboronates are Efficient Intermediates for Selective, Rapid and Reversible N-Terminal Cysteine Functionalisation. Chem Sci 2016; 7: 5052-5058.

Santos FMF, Rosa JN, Candeias NR, Carvalho CP, Matos AI, Ventura AE, Florindo HF, Silva LC, Pischel U, Gois PMP. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes). Chem Eur J 2016; 5: 1631-1637 (VIP paper and cover).

Rocha A., Teixeira R., Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem 2017; 10: 296-302.

Gomes LFR, Veiros LF, Maulide N, Afonso CAM. Diazo- and Transition Metal-Free C-H Insertion: a Direct Synthesis of b-lactams. Chem Eur J 2015; 21: 1449-1453 (Hot paper).

Group Members

PhD Students

Master Students

  • Joana Carvalho