iMed.ULisboa project funded under the Gilead GÉNESE Program 2019
The project “Dementia associated with HIV infection – study of infectious and inflammatory mechanisms mediated by extracellular vesicles”, led by José M. Azevedo Pereira, iMed.ULisboa investigator from the Host-Pathogen Interactions Group was selected to be funded under the Gilead GÉNESE Program 2019 edition . The objective of this project is to (i) define the mechanisms by which HIV establishes and maintains a central nervous system (CNS) infection; (ii) how cells are infected in this compartment; and (iii) what are the mechanisms underlying the neurodegeneration observed in some HIV infected patients under effective antiretroviral therapy. The hypothesis they want to explore is that these processes are mediated by extracellular vesicles (EVs). The team members intend to investigate the contribution of EVs in the dissemination of HIV in CNS as well as in the associated neuroinflammation that characterises HIV-associated neurocognitive disorders.