iMed.ULisboa Seminar for a Healthy Science – Promoting health by addressing the disease
19 February 2021
Next Friday, at 12h, Prof Dora Brites will present the onlibe Seminar dedicated to Promoting health by addressing the disease.
Check the zoom meeting here!
Neuro-immune interactions: A holistic paradigm in CNS pathology and regeneration
Degeneration of neuronal structure and function is a hallmark of neurodegenerative diseases that has been associated to neuroinflammation, involving glial cell activation and disruption of homeostatic cell balance. Evidence shows that astrocytes and microglia display mixed phenotypes differently influencing paracrine and autocrine signals. Secretome-mediated exosome signaling, involving misfolded/mutated proteins, microRNAs and alarmins is a major driver of disease propagation and nearby and far-off cell dysfunction. One of our major goals is to identify cell phenotypic targets and exosomal pathological biomarkers to develop interventional strategies that can delay or even reverse disease progression. This talk will provide a broad oversight on how dysregulation of glial responses associates with neuronal dysfunction and different patient signatures. Examples of exosomes as mediators of intercellular pathophysiology, diagnostic tools and vehicles for neuroregeneration, using human advanced experimental models in the upcoming era of precision medicine, will be presented.
Dora Brites holds a PhD in Biochemistry (1988) and habilitation in Biological Sciences (2004) from the Universidade de Lisboa (ULisboa, Portugal). She is Research Coordinator at the Faculty of Pharmacy of ULisboa, and head of Neuron Glia Biology in Health and Disease at the Research Institute for Medicines (iMed.ULisboa).
She was awarded with the Santa Casa prize in 2015 in Amyotrophic Lateral Sclerosis (ALS) Research Grant and Portuguese team leader of the MADGIC project (European Joint Programme for Neurodegenerative Diseases) in Alzheimer’s disease (AD).
Dora Brites research interests reside on neuroinflammatory signaling pathways and dysregulated neuronal-glia communication in neurodevelopmental/neurodegenerative diseases such as ALS and AD. She recently identified a set of inflammatory-associated miRNAs as determining glia polarization and neurodegeneration.
Presently, her group applies interdisciplinary approaches to target immunophenotypic aberrancies with translation to the clinics. Dora Brites co-authored more than 100 publications (h-index 43).