Pedro R. Florindo

PhD in Inorganic Chemistry, 2008, Universidade de Lisboa
Post-Doctoral Fellow, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID J-2908-2013
Group Researcher ID B-4834-2014
Scopus Author ID 24481090300

Research Interests

Florindo research is focused on design of anticancer organometallic bioconjugates, especially on glycoconjugation as route for selective delivery of metallic cytotoxic payloads in Warburg tumor phenotypes, with important results in the area. With interest also in catalysis and nonlinear optical materials, since joining Moreira’s group his research spanned also to development of serine-protease activity-based probes for chronic obstructive pulmonary disease early detection.

Selected Publications

Cabrita IR, Florindo PR, Costa PJ, Oliveira MC, Fernandes AC. Hydrophosphonylation of aldehydes catalyzed by cyclopentadienyl ruthenium(II) complexes. Molecular Catalysis 2018; 450: 77-86.

Florindo PR, Costa PJ, Piedade MFM, Robalo MP. pH-switchability and second-order nonlinear optical properties of monocyclopentadienylruthenium(II)/iron(II) tetrazoles/tetrazolates: synthesis, characterization, and time-dependent density functional theory calculations. Inorganic Chemistry 2017; 56: 6849-63.

Florindo PR, Pereira DM, Borralho PM, Costa PJ, Piedade MFM, Rodrigues CMP, Fernandes AC. New [(η5-C5H5)Ru(N-N)(PPh3)][PF6] compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Transactions 2016; 45: 11926-30.

Florindo PR, Pereira DM, Borralho PM, Rodrigues CMP, Piedade MFM, Fernandes AC, Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agentes. Journal of Medicinal Chemistry 2015; 58: 4339.

Amat M, Ramos C, Perez M, Molins E, Florindo P, Santos MMM, Bosch J. Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline. Chemical Communications 2013; 49: 1954-56.