Maria J. Gama
PhD (2001) in Pharmacy (Molecular Biology and Genetics), Universidade de Lisboa
Assistant Professor, Biochemistry and Human Biology, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Maria João’s primary research interest focuses on the role of drug metabolizing enzymes (DME) in neurodegenerative diseases, namely Parkinson’s disease (PD). Studies were undertaken to assess the impact of genetic diversity and polymorphism of phase II DME genes developed into risk assessment in neurodegenerative diseases. The main goal of ongoing studies is to further characterize the neuronal protective role of Glutathione S-Transferase pi against dopaminergic cell death using the MPTP PD mouse model.
Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, van Horsen J, Gama MJ. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett 2016; 590: 1455-66.
Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, Rodrigues CMP, Gama MJ, Castro-Caldas M. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. BBA – Molecular Basis of Disease 2017; 1863: 2171-81.
Neves Carvalho A, Marques C, Rodrigues E, Henderson CJ, Wolf CR, Pereira P, Gama MJ. Ubiquitin–proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice. Mol Neurobiol 2013; 47: 662-72.
Castro-Caldas M, Neves Carvalho A, Rodrigues E, Henderson CJ, Wolf CR, Rodrigues CMP, Gama MJ. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson’s disease. Mol Neurobiol 2012; 46: 475-86.
Castro-Caldas M, Neves Carvalho A, Rodrigues E, Henderson CJ, Wolf CR, Gama MJ. Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway. Mol Neurobiol 2012; 45: 466-77.