Beatriz Silva Lima

PhD (1991) in Pharmacy, Universidade de Lisboa
Full Professor, Pharmacological Sciences, Faculdade de Farmácia, Universidade de Lisboa
Group Leader, Pharmacological and Regulatory Sciences at iMed.ULisboa
Program Area Leader, Drug Development at iMed.ULisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID A-4284-2014
Group Researcher ID B-5723-2014
Scopus Author ID 6506345004

Research Interests

Beatriz Silva Lima leads a group investigating: 1) cellular cascades in inflammatory diseases and new pharmacological interventions on diabetes, cancer and infectious diseases, exploring small molecules or natural products. In vivo and in vitro models are used for diabetes, ischemia/reperfusion, chronic inflammation e.g. chron´s disease or reumathoid arthritis. 2) modelling & simulation approaches for Pharmacokinetic/Pharmacodynamic relationships are also covered by this group as well as 3) Regulatory Science approaches to cope with guidelines for translational research to First in Human studies of  investigational products.

Selected Publications

Silva Lima B, Videira, MA. Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies. Mol Ther Methods Clin Dev 2018 31; 8:183-197.

Malmir M, Serrano R, Caniça M, Silva-Lima B, Silva O. A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus. Plants 2018; 7: 20.

De Mello-Sampayo C, Agripino A, Stilwell A, D, Vidal D, B., Fernando AL, Silva-Lima B, Vaz MF, Canhão H, Marques MC. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology 2017; 4603247.

Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK. Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury. Hepatology (Baltimore, Md.) 2017; 65: 710–721.

de Mello-Sampayo C, Paterna A, Polizzi A, Duarte D, Batista I, Pinto R, Gonçalves P, Raymundo A, Batista AP, Gouveia L, Silva-Lima B, Bandarra NM. Evaluation of Marine Microalga Diacronema vlkianum Biomass Fatty Acid Assimilation in Wistar Rats.  Molecules 2017; 22: pii: E1097.