Judite Costa

PhD (1998) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor, Toxicological and Bromatological Sciences, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID A-8359-2014
Group Researcher ID B-4215-2014
Scopus Author ID 7402461239

Research Interests

Since several years Judite Costa scientific interests focus on the development and study of novel macrocyclic compounds for potential biomedical applications namely in chelation therapy and as catalytical antioxidants (SOD mimetics).

Selected Publications

Torres N, Gonçalves S, Fernandes AS, Franco Machado J, Villa de Brito MJ, Oliveira NG, Castro M, Costa J, Cabral MF. [15]aneN4S: Synthesis, thermodynamic studies and potential applications in chelation therapy. Molecules 2014; 19: 550-67.

Fernandes AS, Costa J, Gaspar J, Rueff J, Cabral MF, Cipriano M, Castro M, Oliveira NG. Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells. Free Radical Res 2012; 46: 1157-66.

Gonçalves S, Fernandes AS, Oliveira NG, Marques J, Costa J, Cabral MF, Miranda J, Cipriano M, Guerreiro PS, Castro M. Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of the macrocycle [15]pyN5. Food and Chemical Toxicology 2012; 50, 2180-87.

Fernandes AS, Cabral MF, Costa J, Castro M, Delgado R, Drew MGB, Felix V. Two macrocyclic pentaaza compounds containing pyridine evaluated as novel chelating agents in copper(II) and nickel(II) overload. J Inorg Biochem 2011; 105: 410-19.

Fernandes AS, Gaspar J, Cabral MF, Caneiras C, Guedes R, Rueff J, Castro M, Costa J, Oliveira NG. Macrocyclic copper(II) complexes. Superoxide scaveenging activity, structural studies and cytotoxicity evaluation. J Inorg Biochem 2007; 101: 849-58.