Hélio Faustino

PhD (2014) in Chemical science and technology, Universidade de Santiago de Compostela, Spain

Post-Doctoral Fellow, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID E-1903-2012
Group Researcher ID B-4209-2014
Scopus Author ID 25121396900

Research Interests

Hélio Faustino is a postdoc at the Gois lab and he is currently working in the “Design of iminoboronate based antitumor targeting conjugates”, developing generic synthetic methods to modified peptides and proteins. In this context recently the group disclosed a method for selective, rapid and reversible N-terminal cysteine functionalisation. Previous works include metal catalysis, in particular Gold catalyzed cycloadditions.

Selected Publications

Faustino H, Silva MJSA, Veiros LF, Bernardes GJL, Gois PMP. Iminoboronates are efficient intermediates for selective, rapid and reversible N -terminal cysteine functionalisation. Chem Sci 2016; 7: 5052-5058.

Destito P, R. Couceiro J, Faustino H, Lopez F, Mascareñas JL. Ruthenium-Catalyzed Azide-Thioalkyne Cycloadditions in Aqueous Media (RuAtAC): A Mild, Orthogonal and Biocompatible Chemical Ligation. Angew Chemie Int Ed 2017; 56: 10766-10770.

Faustino H, Varela I, Mascareñas JL, López F. Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans. Chem Sci 2015; 6: 2903-2908.

Faustino H, Alonso I, Mascareñas JL, López F. Gold(I)-Catalyzed Cascade Cycloadditions between Allenamides and Carbonyl-Tethered Alkenes: An Enantioselective Approach to Oxa-Bridged Medium-Sized Carbocycles. Angew Chemie Int Ed 2013; 52: 6526-6530.

Faustino H, López F, Castedo L, Mascareñas JL. Gold(I)-catalyzed intermolecular (4 + 2) cycloaddition of allenamides and acyclic dienes. Chem Sci 2011; 2: 633.