Francisca Lopes

PhD (2000) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Associate Professor, Pharmaceutical Chemistry and Therapeutics, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 476
F (+351) 217 946 470
Researcher ID M-6639-2013
Group Researcher ID B-4834-2014
Scopus Author ID 7005361784

Research Interests

Lopes is involved in the design of antimalarial agents targeting several stages of the malaria parasite’s life-cycle. She pioneered the use of the hybrid drug concept in antimalarial drug discovery. Lopes is developing pro-drugs as targeted delivery systems based on parasite-selective mechanisms such as the Fe(II)-triggered activation of endoperoxides. Currently, she is translating this concept to target Leishmania parasites and to develop tumor activated pro-drugs. Additionally, she is developing new lead compounds for tuberculosis treatment.

Selected Publications

Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque I, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem 2018; 149: 69-78.

Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O’Neill PM, Lopes F. Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials. J Med Chem 2014; 57: 4916-4923.

Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O’Neill P, Lopes F. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med Chem Lett 2014; 5: 108-112.

Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O’Neill PM, Ward SA, Lopes F, Moreira R. An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites. Chem Med Chem 2013; 8: 1528- 1536.

Rodrigues T, da Cruz FP, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Moreira R, Lopes F. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem 2013,69, 872-880.

Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O’Neill P, Mota MM, Lopes F, Moreira R. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: towards increased potency and metabolic stability. J Med Chem. 2013; 56: 7679-7690.