Filipa F. Vale
PhD (2008) in Biomedical Engineering, Universidade Católica Portuguesa
Post-Doctoral Fellow, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Research Interests
Pathogen genomics and phylogenetics to understand host-pathogen interactions, epidemiology, virulence, disease and evolution. Comparative genome analysis and population structure of Helicobacter pylori. Exploiting H. pylori phage genomics, providing insights into phage diversity, evolution and biomedical applications. Innovative therapeutic solutions for multidrug resistant Gram-negative infections. Development of new biopharmaceutical antibacterials from phage gene products.
Selected Publications
Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, Vítor JM, Engstrand L, Pascoe B, Berthenet E, Sheppard SK, Hitchings MD, Mégraud F, Vadivelu J, Lehours P. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Sci Rep 2017; 7:42471.
Vale FF, Vadivelu J, Oleastro M, Breurec S, Engstrand L, Perets TT, Mégraud F,Lehours P. Dormant phages of Helicobacter pylori reveal distinct populations in Europe. Sci Rep 2015; 5, 14333.
Oleastro M, Rocha R, Vale FF. Population genetic structure of Helicobacter pylori strains from Portuguese speaking countries. Helicobacter 2017; 22.
Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, Oleastro M. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter 2017; 22.
Lehours Philippe, Vale Filipa F, Bjursell M, Melefors O, Advani R, Glavas S, Guegueniat J, Gontier E, Lacomme S, Matos AA, Menard A, Mégraud F, Engstrand L, Andersson A. Genome sequencing reveals a phage in Helicobacter pylori. MBio 2011; 2: e00239-11.