Filipa Siopa

PhD (2011) in Chemistry, Universidade Nova de Lisboa
Post-Doctoral Fellow, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID M-8113-2013
Group Researcher ID B-4209-2014
Scopus Author ID 21234394200

Research Interests

Filipa Siopa is a Post-Doc researcher under the supervision of Professor Carlos Afonso. The main topic of the research focus in the synthesis of bicyclic beta-lactams by photochemical transformation of pyridinium salts and in the valorization of bicyclic-aziridines, which includes ring-opening in water under mild conditions with bionucleophiles and bioconjugation reactions. The application of photochemical transformations under continuous-flow is also a topic of her research. Additionally she is involved in the synthesis of choline-based ionic liquids and in the studied of their biological activity. These compounds have been tested in several targets including malaria disease, human colon adenocarcinoma cell line (HT-29) and ChoK. The antimicrobial activity of these ILs was evaluated, as well as, their inhibition activity against acetylcholinesterase. F. Siopa also synthesized photochromic compounds for the production ‘Two-Photon Activated Photochromic Polymers’ for optical data storage.

Selected Publications

Sintra TE, Nasirpour M, Siopa F, Rosatella AA, Gonçalves F, Coutinho JAP, C.A.M. Afonso CAM, Ventura SPM. Ecotoxicological evaluation of magnetic ionic liquids. Ecotox Environ Safe 2017; 143: 315-321.

Vale JR, Siopa F, Branco PS, Afonso CAM. Ring Opening of 6-Azabicyclo[3.1.0]hex-3-en-2-ols in Water under Mild Conditions. Eur J Org Chem 2016; 11: 2048–2053.

Mariz IFA, Siopa F, Rodrigues CAB, Afonso CAM, Chen X, Martinho, JMG, Maçôas EMS. A 1,3,5-triazine based polymer as a nonlinear near-infrared antenna for two-photon activated volumetric optical memory devices. J Mater Chem C 2015; 3: 10775-10782.

Hartmann DO, Shimizu K, Siopa F, Leitão MC, Afonso CAM, Canongia JNL, Silva CP. Plasma membrane permeabilisation by ionic liquids: a matter of charge. Green Chemistry 2015; 17: 4587-4598.

Frade RFM, Simeonova S, Rosatella AA, Siopa F, Afonso CAM. Toxicological Evaluation of Magnetic Ionic Liquids in Human Cell Lines. Chemosphere 2013; 92: 100–105.