PhD (1998) in Pharmacy (Microbiology), Universidade de Lisboa
Post-Doctoral Fellow, EMBL, Heidelberg, Germany
Associate Professor, Microbiology and Immunology, Faculdade de Farmácia
Group Leader, Host-Pathogen Interactions at iMed.ULisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
The aim of our research is to give insights into the host factors that facilitate pathogen killing. Macrophages and dendritic cells play a major role during infection acting as key effector cells in pathogen killing and antigen presentation. Elsa Anes leads a group with pioneer studies in deciphering (1) how to manipulate actin dynamics for phagosome maturation, (2) inflammasome activation, (3) cathepsins or their inhibitors acquisition and trafficking host factors required to boost the innate killing propensity of host cells.
Anes E, Kuhnel MP, Bos E, Moniz-Pereira J, Grittiths G. Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nat Cell Biol 2003; 5: 793-0802.
Mishra BB, Moura- Alves P, Sonawane A, Hacohen N, Griffiths G, Moita LF, Anes E. Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cell Microbiol 2010; 12: 1046-1063.
Pires D, Marques J, Pombo JP, Carmo N, Bettencourt P, Neyrolles O, Lugo-Villarino G and Anes E. Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages. Sci Rep 2016; 6:32247.
Jordao L, Bleck CKE, Mayorga L, Griffiths G, Anes E. On the killing of mycobacteria by macrophages. Cell Microbiol 2008; 10: 529-548.
Bettencourt P, Marion S, Pires D, Santos L, Lastrucci C, Carmo N, Blake J, Benes V, Griffiths G, Neyrolles O, Lugo-Villarino G, Anes E. Actin-binding protein regulation by microRNAs as a novel microbial strategy to modulate phagocytosis by host cells: the case of N-Wasp and miR-142-3p. Front Cell Infect Microbiol 2013; 3: 19.