Carlos A. M. Afonso

PhD (1984) in Organic Chemistry, Universidade Nova de Lisboa
Full Professor, Pharmaceutical Chemistry and Therapeutics, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID M-7833-2013
Group Researcher ID B-4209-2014
Scopus Author ID 19336779300

Research Interests

Carlos A. M. Afonso leads an organic chemistry team exploring the following main topics: New catalyzed synthetic methodologies (metal organocatalyzed synthesis of carbocycles, C-H insertion of carbenoid intermediates, photochemical rearrangements), green chemistry (reactions in water, ionic liquids, PEG, solvent free, catalyst reuse, membrane technology), synthetic valorization of national natural resources, development of new materials (ionic liquids, two-photon probes), biotransformations.


Selected Publications

Rocha A, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem 2017; 10: 296-302.

Ventura SPM, Morais P, Coelho JAS, Sintra T, Coutinho JAP, Afonso CAM. Evaluating the toxicity of biomass derived platform chemicals. Green Chem 2016; 18: 4733-4742.

Gomes LFR, Veiros LF, Maulide N, Afonso CAM. Diazo- and Transition Metal-Free C-H Insertion: a Direct Synthesis of b-lactams. Chem Eur J 2015; 21: 1449-1453 (Hot paper).

Sowmiah S, Veiros LF, Esperança JMSS, Rebelo LPN, Afonso CAM. Organocatalyzed one-step synthesis of functionalized N-alkyl-pyridinium salts from biomass derived 5-hydroxymethylfurfural. Organic Letters 2015; 17: 5244-5247.

Gomes RFA, Coelho JAS, Frade RFM, Trindade AF, Afonso CAM. Synthesis of Symmetric Bis(N-alkylaniline)triarylmethanes via Friedel Crafts-Catalyzed Reaction between Secondary Anilines and Aldehydes. J Org Chem 2015; 80: 10404-10411.