Ana Bettencourt

PhD (2006) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor with Agregation, Toxicological and Bromatological Sciences, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID M-4219-2013
Group Researcher ID B-4215-2014
Scopus Author ID 6603687672

Research Interests

Bettencourt major research interests are in the improvement of the therapeutic effects of local drug-delivery-systems for application in biomaterials-associated-infections (dental and orthopaedic). Specifically, novel strategies to overcome implant-associated infections are being developed mainly by the production and complete characterization (mechanical, physical and biological) of innovative polymeric local-drug delivery devices with controlled release properties and high anti-biofilm activity against multi-resistant pathogens.

Selected Publications

Martin V, Ribeiro IA, Alves MM, Gonçalves L, Claudio RA, Grenho L, Fernandes MH Gomes P, Santos CF, Bettencourt AF. Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration. Mater Sci Eng C Mater BiolAppl. 2019; 101:15-26.

Woischnig AK, Gonçalves LM, Ferreira M, Kuehl R, Kikhney J, Moter A, Ribeiro IAC, Almeida AJ, Khanna N,Bettencourt AF. Acrylic microparticles increase daptomycin intracellular and in vivo anti-biofilm activity against Staphylococcus aureus. Int J Pharm. 2018; 550: 372-379.

Graça D, Louro H, Santos J, Dias K, Almeida AJ, Gonçalves L, Silva MJ, Bettencourt A. Toxicity screening of a novel poly(methylmethacrylate)-Eudragit nanocarrier on L929 fibroblasts. Toxicol Lett. 2017; 276:129-137.

Santos-Ferreira I, Bettencourt A, Gonçalves LM, Kasper S, Bétrisey B, Kikhney J, Moter A, Trampuz A, Almeida AJ. Activity of Daptomycin and vVancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms. Int J Nanomedicine. 2015; 10:4351-66.

Matos A, Ribeiro I, Guedes R, Pinto R, Vaz M, Gonçalves L, Almeida AJ, Bettencourt A. Key-properties Outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery. Int J Pharm. 2015; 85: 317-28.