Adelaide Fernandes

PhD (2006) in Pharmacy (Biochemistry), Universidade de Lisboa
Assistant Professor, Biochemistry and Human Biology, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 491
Researcher ID A-4787-2011
Group Researcher ID B-5403-2014
Scopus Author ID 8896201000

Research Interests

Adelaide research focus on the role of neuroinflammation in neurodevelopment and neurodegenerative disorders. Adelaide addresses the relevance of microglia/astrocyte-neuron interplay in Alzheimer’s disease, exploring the role of microRNAs and vesicle-mediated cellular communication in relevant disease models as patient-derived iPSCs. Adelaide is also interested in inflammatory demyelinating disorders, as Multiple Sclerosis, addressing how glia and immune response may modulate oligodendrogenesis and so disease pathogenesis and psycopathology.

Selected Publications


Santos G, Barateiro A, Gomes C, Brites D, Fernandes A. Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment. Neuropharmacology 2018; 129: 69-83.

Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D. Key aging-associated alterations in primary microglia response to beta-amyloid stimulation. Front Aging Neurosci 2017; 9: 277.

Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A. S100B as a biomarker and therapeutic target in multiple sclerosis. Mol Neurobiol 2016; 53: 3976-91.

Barateiro A, Miron VE, Santos SD, Relvas JB, Fernandes A, Ffrench-Constant C, Brites D. Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination. Mol Neurobiol 2013; 47: 632-644.

Fernandes A, Barateiro A, Falcão AS, Silva SL, Vaz AR, Brito MA, Silva RFM, Brites D. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. GLIA 2011; 59: 14-25.