Pharmacological and Regulatory Sciences

Group Leader

Maria Beatriz da Silva Lima

PhD (1991) in Pharmacy, Universidade de Lisboa
Full Professor, Faculdade de Farmácia, Universidade de Lisboa
Program Area Leader, Drug Development at iMed.ULisboa

The Research

Our research spans over the multiple aspects of drug development including strategies of preclinical development, methodologies for predicting the human safe use of drugs and the impact of preclinical findings on drug usage. The approaches used are enriched with the regulatory requirements in place internationally to allow appropriate translation of any experimental data into human situations. The group is highly experienced in the development and use of modeling and simulation approaches using in silico and/or in vitro systems to predict the transport of molecules across cell membranes, and the ADME characteristics. Additionally, the group is highly involved in training activities, many international within multiple consortia involving European Universities and pharmaceutical industry.


Ongoing Projects

Source: Projeto LIFE, Life14 ENV/PT/000739
Title: Life IMPETUS – “Improving current barriers for controlling pharmaceutical compounds in urban wastewater treatment systems”
PI: Cristina Almeida (FFUL)/Maria João Rosa (LNEC, Project leader)
Period: 2016-2019

Source: HOME/2014/JDRU/AG/DRUG/7086
Title: NPS-EURONET – Identification and assessment of new psychoactive substances: a European network.
PI:  Ettore Zuccato (Mario Negri Institute); Team members: Cristina Sampayo, Nuno Silva and Paulo Paixão (FFULisboa).
Period: 2016-2018

Traget4Cancer, (Nano) systems with active targeting to sensitize colorectal cancer stem cells to anti-tumoral treatment, ERA-NET EuroNanoMed-II; Mafalda Videira (FFULisboa).
Period: 2016-2019

COST Action MP1404, “SimInahle”; Mafalda Videira (Leader) and Beatriz Silva Lima (FFULisboa).
Period: 2015-2019

Recent Most Relevant Publications

van der Laan JW, Kasper P, Silva Lima B, Jones DR, Pasanen M. Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties.  Critical Reviews in Toxicology. 2016; Aug;46(7):587-614.

Encarnacao S, de Mello-Sampayo C, Graca NAG, Catarino L, da Silva IBM, Lima BS, Silva OMD. Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation. Industrial Crops and Products. 2016; 82: 171-8.

Arranja A, Gouveia LF, Gener P, Rafael DF, Pereira C, Schwartz S Jr, Videira MA. Self-assembly PEGylation assists SLN-Paclitaxel delivery inducing cancer cell apoptosis upon internalization. International Journal of Pharmaceutics. 2016; Mar 30;501(1-2):180-9. Epub 2016 Feb 4.

Bandarra NM, Lopes PA, Martins SV, Ferreira J, Alfaia CM, Rolo EA, Correia JJ, Pinto RMA, Ramos-Bueno RP, Batista I, Prates JAM, Guil-Guerrero JL. Docosahexaenoic acid at the sn-2 position of structured triacylglycerols improved n-3 polyunsaturated fatty acid assimilation in tissues of hamsters. Nutrition Research. 2016; 36(5);452-63. (Doi: 10.1016/j.nutres.2015.12.015)

Gaffney VD, Mota-Filipe H, Pinto RA, Thiemermann C, Loureiro M, Cardoso VV, Benoliel MJ, Almeida CMM. Chemical and Biochemical Characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental Toxicology and Chemistry. 2016; 35(11);2674-82.

Group Members

PhD Students

  • Inês Gouveia
  • Katelene Lima
  • Marta Carvalho
  • Maryam Malmir
  • Patrícia Afonso
  • Quintino Málu
  • Sofia Encarnação
  • Telma Cordeiro

Master Students

  • Alfredo Dique
  • Bruna Kreutzer
  • Miguel Monteiro
  • Patrícia Antunes
  • Salomé Fletcher
  • Zhang Guanghong