Pharmacological and Regulatory Sciences
Maria Beatriz da Silva Lima
Full Professor, Faculdade de Farmácia, Universidade de Lisboa
Program Area Leader, Drug Development at iMed.ULisboa
Our research spans over the multiple aspects of drug development including strategies of preclinical development, methodologies for predicting the human safe use of drugs and the impact of preclinical findings on drug usage. The approaches used are enriched with the regulatory requirements in place internationally to allow appropriate translation of any experimental data into human situations. The group is highly experienced in the development and use of modeling and simulation approaches using in silico and/or in vitro systems to predict the transport of molecules across cell membranes, and the ADME characteristics. Additionally, the group is highly involved in training activities, many international within multiple consortia involving European Universities and pharmaceutical industry.
Source: Projeto LIFE, Life14 ENV/PT/000739
Title: Life IMPETUS – “Improving current barriers for controlling pharmaceutical compounds in urban wastewater treatment systems”
PI: Cristina Almeida (FFUL)/Maria João Rosa (LNEC, Project leader)
Title: NPS-EURONET – Identification and assessment of new psychoactive substances: a European network.
PI: Ettore Zuccato (Mario Negri Institute); Team members: Cristina Sampayo, Nuno Silva and Paulo Paixão (FFULisboa).
Traget4Cancer, (Nano) systems with active targeting to sensitize colorectal cancer stem cells to anti-tumoral treatment, ERA-NET EuroNanoMed-II; Mafalda Videira (FFULisboa).
Recent Most Relevant Publications
van der Laan JW, Kasper P, Silva Lima B, Jones DR, Pasanen M. Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties. Critical Reviews in Toxicology. 2016; Aug;46(7):587-614.
Encarnacao S, de Mello-Sampayo C, Graca NAG, Catarino L, da Silva IBM, Lima BS, Silva OMD. Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation. Industrial Crops and Products. 2016; 82: 171-8.
Arranja A, Gouveia LF, Gener P, Rafael DF, Pereira C, Schwartz S Jr, Videira MA. Self-assembly PEGylation assists SLN-Paclitaxel delivery inducing cancer cell apoptosis upon internalization. International Journal of Pharmaceutics. 2016; Mar 30;501(1-2):180-9. Epub 2016 Feb 4.
Bandarra NM, Lopes PA, Martins SV, Ferreira J, Alfaia CM, Rolo EA, Correia JJ, Pinto RMA, Ramos-Bueno RP, Batista I, Prates JAM, Guil-Guerrero JL. Docosahexaenoic acid at the sn-2 position of structured triacylglycerols improved n-3 polyunsaturated fatty acid assimilation in tissues of hamsters. Nutrition Research. 2016; 36(5);452-63. (Doi: 10.1016/j.nutres.2015.12.015)
Gaffney VD, Mota-Filipe H, Pinto RA, Thiemermann C, Loureiro M, Cardoso VV, Benoliel MJ, Almeida CMM. Chemical and Biochemical Characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental Toxicology and Chemistry. 2016; 35(11);2674-82.
Maria Beatriz da Silva Lima,
T +351 217 946 400
- Ana Paula Carrondo
- Bruno Sepodes
- Cristina Almeida
- Cristina Luzia de Mello Sampayo
- Helder Mota Filipe
- Isabel Bettencourt Moreira da Silva
- João Rocha
- José Guimarães Morais
- Mafalda Videira
- Maria Eduardo Figueira
- Maria Margarida Estudante
- Nuno M. Silva
- Olga Maria Duarte Silva
- Paulo Paixão
- Pedro Pinto
- Rita Serrano
- Rui Amaro Pinto
- Vanessa Mateus
- Inês Gouveia
- Katelene Lima
- Marta Carvalho
- Maryam Malmir
- Patrícia Afonso
- Quintino Málu
- Sofia Encarnação
- Telma Cordeiro
- Alfredo Dique
- Bruna Kreutzer
- Miguel Monteiro
- Patrícia Antunes
- Salomé Fletcher
- Zhang Guanghong