Pharmacological and Regulatory Sciences
Beatriz da Silva Lima
Full Professor, Faculdade de Farmácia, Universidade de Lisboa
Program Area Leader, Drug Development at iMed.ULisboa
Our research spans over the multiple aspects of drug development including strategies of preclinical development, methodologies for predicting the human safe use of drugs and the impact of preclinical findings on drug usage. The approaches used are enriched with the regulatory requirements in place internationally to allow appropriate translation of any experimental data into human situations. The group is highly experienced in the development and use of modeling and simulation approaches using in silico and/or in vitro systems to predict the transport of molecules across cell membranes, and the ADME characteristics. Additionally, the group is highly involved in training activities, many international within multiple consortia involving European Universities and pharmaceutical industry.
Source: EU LIFE Environment Programme (LIFE14 ENV/PT/000739)
Title: Life IMPETUS – Improving current barriers for controlling pharmaceutical compounds in urban wastewater treatment systems
PI: Maria João Rosa (LNEC); Participant: Cristina Almeida
Source: EU Drugs policy initiatives JUST/2014/JDRU/AG/DRUG (HOME/2014/JDRU/AG/DRUG/7086)
Title: NPS-EURONET – Identification and assessment of new psychoactive substances: a European network.
PI: Ettore Zuccato (Mario Negri Institute, Italy); Participant: Cristina Sampayo
Source: ERANet EuroNanoMed2 European Innovative Research & Technological Development Projects in Nanomedicine
Title: Target4Cancers – Nano systems with active targeting to sensitize colorectal cancer stem cells to antitumoral treatment
PI: Simo Schwartz (Barcelona, Spain); Participant: Mafalda Videira
Recent Most Relevant Publications
Mateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto R. Thiadiazolidinone-8 Ameliorates Inflammation Associated with Experimental Colitis in Mice. Pharmacology 2018;101: 35-42.
Sheean ME, Stoyanova-Beninska V, Capovilla G, Duarte D, Hofer MP, Hoffmann M, Magrelli A, Mariz S, Tsigkos S, Shaili E, Polsinelli B, Ricciardi M, Bonelli M, Balabanov P, Larsson K, Sepodes B. Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions. Drug Discovery Today 2018; 23: 26-48.
Rafael D, Gener P, Andrade F, Seras-Franzoso J, Montero S, Fernández Y, Hidalgo M, Arango D, Sayós J, Florindo HF, Abasolo I, Schwartz S Jr, Videira M. AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells. Drug Deliv 2018; 25: 961-972.
Malmir M, Serrano R, Caniça M, Silva-Lima B, Silva O (2018). A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus. Plants 2018; 7: 20.
Cavaco MC, Pereira C, Kreutzer B, Gouveia LF, Silva-Lima B, Brito AM, Videira M. Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles. Eur J Pharm Biopharm 2017; 110: 76-84.
Beatriz da Silva Lima,
- Ana Paula Carrondo
- Bruno Sepodes
- Cristina M. M. Almeida
- Cristina Sampayo
- Helder Mota Filipe
- Isabel Moreira da Silva
- João Rocha
- José A. Guimarães Morais
- Luís F. P. Gouveia
- Mafalda Videira
- Maria Eduardo Figueira
- Maria Margarida Estudante
- Nuno M. Silva
- Olga Silva
- Paulo Paixão
- Pedro Pinto
- Rita Serrano
- Rui Amaro Pinto
- Vanessa Mateus
- André Horta
- Katelene Lima
- Maria dos Anjos Valente
- Maryam Malmir
- Quintino Málu
- Rosa Direito
- Sofia Encarnação
- Telma Cordeiro
- Miguel Monteiro
- Patrícia Antunes
- Salomé Fletcher