BioNanoSciences – Drug Delivery and Immunotherapy (BioNanoSci)

Group Leader

Helena F. Florindo

PhD (2008) in Pharmaceutical Technology, Universidade de Lisboa, NL
Assistant Professor
 

The Research

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Our research is focused on the mechanisms of cellular dynamics, cross-talk and networks, including the characterization of specific cell membrane-material interactions, to identify new targets that will guide the engineering of translational nanotechnology-based systems for drug delivery, imaging and immunotherapy in specific clinically relevant situations (cancer, inflammation, genetic diseases). Novel formulation procedures are currently being adapted to microfluidic technics to support the continuous control of those methodologies aiming at translational nanomedicines. We are particularly interested on the identification of process parameters critical for targeted nanoparticle quality attributes, which control will be attained through the application of Process Analytical Technologies (PAT).

BioNanoSci group comprises complementary teams led by independent researchers that combine their research skills towards the development of controlled nanodelivery systems for immunomodulation, imaging and disease therapy.

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Ongoing Projects

Source: ERA-NET EuroNanoMed II (ENMed/0051/2016)
Title: MultiNano@MBM: Modulation of melanoma-stroma interactions using a rationally-designed nanomedicine combining BRAFi-, MEKi- and immune-therapies
PI: Helena Florindo
Period: 2017-2020

Source: COMPETE2020 and FCT (SAICTPAC/0019/2015)
Title: POINT4PAC – Precision Oncology by Innovative Therapies and Technologies
Local PI: Helena Florindo
Period: 2017-2019

Source: FCT PTDC/BBB-BQB/3710/2014
Title: Atyp-SLs: Biophysical and biological properties of atypical sphingolipids: implications to physiology and pathophysiology
PI: Liana C. Silva
Period: 2016-2019

Source: FCT PTDC/BBB-BQB/6071/2014
Title: RESYEAST: Sphingolipid organization in the plasma membrane of Saccharomyces cerevisiae. Implication in antifungal mode of action and fungal resistance.
Local PI: Liana C. Silva
Period: 2016-2019

Source: FCT UT Austin-Portugal Program (UTAP-ICDT/DTP-FTO/0016/2014)
Title: MultiNanoVac: Multidisciplinary strategy to develop novel multicomponent nanoscale systems for immune modulation metastatic phenotype
PI: Helena Florindo
Period: 2015-2018

Source Hovione FarmaCiencia SA
Title: Dissolution of Dry Powder Inhaler formulations: in vitro/in vivo correlations
PI: M. Luísa Corvo
Period: 2015-2019

Source Hovione FarmaCiencia SA
Title: Biopharmaceuticals Formulations for Dry Powder Inhalers
PI: M. Luísa Corvo
Period: 2015-2019

Source: Phospholipd Research Center (Heidelberg)
Title: Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury
PI: M. Luísa Corvo
Period: 2017-2019

 

Recent Most Relevant Publications

Silva JM, Zupancic E, Vandermeulen G, Oliveira V, Salgado A, Videira M, Gaspar M, Graça L, Préat V*, Florindo HF. In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumour immune responses in a melanoma model. J Control Release 2015; 198C; 91-103.

Zupančič E, Curato C, Paisana M, Rodrigues C, Porat Z, Viana AS, Afonso CA, Pinto J, Moreira JN, Gaspar R, Satchi-Fainaro R, Jung S, Florindo HF. Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming. J Control Release 2017; 28: 182-195

Carreira AC, Almeida RFM, Silva LC. Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties. Sci Rep. 2017; 7(1):3949.

Marcelino P, Marinho HS, Campos MC, Neves AR, Real C, Fontes FS, Carvalho A, Feio G, Martins MBF, Corvo ML. Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy. Eur J Pharm Sci. 2017 Nov 15;109:464-471.

Sainz V, Peres C, Ciman T, Rodrigues C, Viana AS, Afonso CA, Barata T, Gaspar RS, Brocchini S, Zloh M, Florindo HF, Lopes JA. Optimization of protein loaded PLGA nanoparticles manufacturing parameters following a quality-by-design approach. RSC Adv. 2016; 6(106): 104502-104512

Group Members

PhD Students

Master Students

  • Lara Igrejas

Trainees

  • Ariana Colaço
  • Marta Santos
  • Rita Lemos