Innovative Platforms for Non-parenteral Delivery Systems

Group Leader

Helena Maria Cabral Marques

PhD (1991) in Pharmacy (Pharmaceutical Technology), Universidade de Lisboa
Associate Professor with habilitation, Faculdade de Farmácia, Universidade de Lisboa


The Research


Our group is focused on the development of innovative drug delivery systems (technology platforms), through a multidisciplinary approach integrating materials engineering and physico-chemical characterization. The research conducted is based on the design and development of new carriers for drug transport (polymers, sugars, cellulose derivatives, cyclodextrins) using innovative technologies (spray-drying, freeze-drying, supercritical fluids), and the characterization of these systems and respective materials (e.g. polymorphs state). The main technology platforms are based on the use of micro- and nano-based dosage forms (macromolecular complexation and/or particle engineering) and are prepared from materials of different nature used for the transport of different bioactive agents for specific diseases.


Target organ/tissue reached by innovative platforms for non-parenteral delivery systems.

Ongoing Projects

Source: FCT (PTDC/CTM-BIO/3946/2014)
Title: Production of micro and nanosized coamorphous materials with therapeutic activity (nanoCoAmorph)
PI: João F. Pinto
Period: 2016-2019

Recent Most Relevant Publications

JP Aguiar, TAP Fernandes, C Nesse, AI Fernandes, JF Pinto (2017) Production and characterization of spray-dried theophylline powders for pediatric use prepared from fresh milk, J. Pharm. Pharmacol. 69:554–566.

MC Paisana, MA Wahl, JF Pinto (2017) An Insight Into the Impact of Polymers on the Hydrate Conversion of Olanzapine Form I in Aqueous Suspensions, J. Pharm. Sci. 106:1786-1794

Í. Duarte, M. L. Corvo, P. Serôdio, J. Vicente, J. F. Pinto, M. Temtem, (2016) Production of nano-solid dispersions using a novel solvent-controlled precipitation process — Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying, Eur. J. Pharm. Sci. 93:203–214.

N. Drumond, A. Sá Couto, Ana Costa, H.M. Cabral-Marques, Study of aerodynamic and release properties of inhaled particles containing cyclodextrins. J Incl Phenom Macrocycl Chem (2014) 80(1-2):25–30. DOI: 10.1007/s10847-014-0400-z

Salústio PJ, Feio G, Figueirinhas JL, Pinto JF, Cabral-Marques HM. The influence of the preparation methods on the inclusion of model drugs in a b-cyclodextrin cavity. Eur J Pharm Biopharm. 2009; 71: 377-86.




Group Members

Helena Maria Cabral Marques,
Associate Professor with habilitation
T +351 217 946 400
(Ext. 14242)

PhD Students

Master Students

  • Jéssica Fernandes
  • Mauro Duarte
  • Ana Pires
  • Inês Cachola
  • Maria Inês Barreiros