iMed.ULisboa researcher awarded with a biomedicine and health research project grant by Fundação “la Caixa” and FCT
Rui Castro, researcher of the Cellular Function and Therapeutic Targeting group at iMed.ULisboa received one of the eight health research grants awarded to Portugal by the “Iniciativa Ibérica de Investigação e Inovação Biomédica- i4b”, funded by “la Caixa” Banking Foundation and “Fundação para a Ciência e a Tecnologia (FCT)”
The project will receive around 500.000€ and intends to characterize mechanisms responsible for the development of obesity and non-alcoholic fatty liver disease (NAFLD), particularly those involving signal transduction between the adipose tissue and the liver. Obesity is the main risk factor associated with development of NAFLD. Due to its increasing incidence and prevalence, as well as the lack of pharmacological treatments, obesity and NAFLD pose a worrying clinic, economic and societal burden. To tackle this challenge, this project will further explore the role of microRNAs and bile acid-derivatives as potential disease biomarkers and therapeutic agents.
Other projects awardees included researchers from Instituto de Medicina Molecular (iMM, Lisbon), Fundação Champalimaud (FC, Lisbon), Fundação Calouste Gulbenkian (FCG, Lisbon), Centro de Neurociências e Biologia Celular (CNC, Coimbra), Universidade do Minho (UM, Braga) and Universidade do Porto (U.Porto, Porto).