Development of vaccines against listeriosis
29 June 2018
Ricardo Calderón González, PhD
Biomedicine and Molecular Biology
Nanovacunas y vacunas celulares basadas en Listeria monocytogenes y sus aplicaciones en Biomedicina
Instituto de Investigación Marqués de Valdecilla, Madrid, Spain
Host: Elsa Anes
Faculdade de Farmácia, Universidade de Lisboa
Listeria monocytogenes is a food-borne pathogen with an increasing incidence in the last years. It’s able to cause an infection, called listeriosis, which in people with a special immunological situation causes severe damage like encephalitis, meningitis, miscarriage or serious neurological effects in newborns.
Our work shows the need of taking actions, finding incidences far above the national average in two communities in Northern Spain. Because of this, we used several vaccines based on peptides of L. monocytogenes in different preclinical studies.
Although dendritic vaccines are safe and give high levels of protection, their clinical application is difficult and expensive. Finally, we used nanovaccines. These novel vaccines, in combination with adjuvants, provide high levels of protection against the disease in models of low risk and high risk of getting the disease, being an optimal alternative for prevention.