Invited Speaker Seminar Series
Identification and characterization of Chlamydia trachomatis virulence proteins
15 March 2019
Jaime Mota, PhD, UCIBIO, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
Host: Elsa Anes
Faculdade de Farmácia, Universidade de Lisboa
Chlamydia trachomatis is an obligate intracellular bacterium, which is an important human pathogen that delivers several effector proteins into host cells. Some of these effectors, known as Inc proteins, insert in the membrane of the vacuole where C. trachomatis resides and multiplies intracellularly; other C. trachomatis effectors are delivered into the host cell cytosol, from where they can target distinct host cell compartments and organelles. For a long time, studies of C. trachomatis molecular pathogenesis have been hindered by lack of genetic tools for its manipulation. However, these tools have recently been developed and we are using them in our ongoing studies to identify and characterize C. trachomatis effectors. I will present our studies on: (i) an Inc protein that interferes with host cell cytokinesis; (ii) a Chlamydia effector that localizes at the Golgi and host cell plasma membrane at distinct times of infection and which might interfere with eukaryotic vesicular trafficking.