Vasco Rui Veloso Neves Branco

PhD (2012) in Pharmacy (Toxicology), Universidade de Lisboa
Post-Doc Researcher

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID C-1144-2014
Group Researcher ID B-4215-2014
Scopus Author ID 8271087300

Research Interests

Vasco Branco’s research concerns how the interaction between mercury compounds and antioxidant systems (thioredoxin; glutathione) modulates the unfolding of neurodevelopmental toxicity. Namely, the research is focused on understanding how mercury affects microglia activation and neural stem cell differentiation. Knowledge of these early toxic events is a key tool for identifying potential biomarkers of early effect to be used in Human Risk Assessment. How selenium compounds interact with mercurials and modify toxicity is also an interest.

Selected Publications

 

Branco V, Coppo L, Solá S, Lu J, Rodrigues CMP, Holmgren A, Carvalho C. Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury. Redox Biol 2017; 13: 278-287.

Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho, C, Holmgren A, Lu J. Thioredoxin and Glutathione Systems Mediated Redox Signaling in Central Nervous System. Antioxid Redox Sign 2017 (in press).

Branco V, Caito S, Farina M, Rocha JBT, Aschner M, Carvalho C. Biomarkers of Mercury Toxicity: Past, Present and Future Trends. J Toxicol Environ Health B 2017; 20: 119-154.

Branco V, Godinho-Santos A, Gonçalves J, Lu J, Holmgren A, Carvalho C. Mitochondrial thioredoxin reductase inhibition, selenium status and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds. Free Radic Biol Med 2014; 73: 95-105.

Branco V, Canário J, Lu J, Holmgren A, Carvalho C. Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med 2012; 52: 781-793.