Vasco Rui Veloso Neves Branco
PhD (2012) in Pharmacy (Toxicology), Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Research focus is on the interaction of mercury compounds with the enzymes of the thioredoxin system, thioredoxin and thioredoxin reductase. Namely, I am trying to understand how inhibition of these enzymes relates with the triggering of cell death upon exposure to mercury. This will allow us to identify a possible biomarker predictive of mercury toxicity. Also, my research addresses how selenium compounds interact with mercurials and alter their toxicity to the thioredoxin system and cells.
Branco V., Godinho-Santos, A., Gonçalves, J. Lu, J., Holmgren, A., Carvalho, C. Mitochondrial thioredoxin reductase inhibition, selenium status and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds. Free Radical Biology and Medicine 2014; 73: 95-105;
Branco, V., Ramos, P., Canário, J., Lu, J., Holmgren, A., Carvalho, C. Biomarkers of adverse response to mercury: histopathology vs. thioredoxin reductase activity. Journal of Biomedicine and Biotechnology – Special Issue on Mercury Toxicity 2012; doi:10.1155/2012/359879;
Branco, V., Canário, J.,Lu, J. Holmgren, A., Carvalho, C. Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radical Biology and Medicine 2012; 52: 781-793.
Branco, V., Canário, J., Holmgren, A., Carvalho, C. Inhibition of the Thioredoxin System in the Brain and Liver of Zebra-Seabreams Exposed to Waterborne Methylmercury. Toxicology and Applied Pharmacology 2011; 251: 95-103.
Branco, V., Vale, C., Canário, J., Santos, M.N. Mercury and Selenium in blue shark (Prionace glauca, L. 1758) and swordfish (Xiphias gladius, L. 1758) from two areas of the Atlantic Ocean. Environmental Pollution, 2007; 150: 373-380.