Vasco Rui Veloso Neves Branco

PhD (2012) in Pharmacy (Toxicology), Universidade de Lisboa
Post-Doc Researcher

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID C-1144-2014
Group Researcher ID B-4215-2014
Scopus Author ID 8271087300

Research Interests

Research focus is on the interaction of mercury compounds with the enzymes of the thioredoxin system, thioredoxin and thioredoxin reductase. Namely, I am trying to understand how inhibition of these enzymes relates with the triggering of cell death upon exposure to mercury. This will allow us to identify a possible biomarker predictive of mercury toxicity. Also, my research addresses how selenium compounds interact with mercurials and alter their toxicity to the thioredoxin system and cells.

Selected Publications

Branco V., Godinho-Santos, A., Gonçalves, J. Lu, J., Holmgren, A., Carvalho, C. Mitochondrial thioredoxin reductase inhibition, selenium status and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds. Free Radical Biology and Medicine 2014; 73: 95-105;

Branco, V., Ramos, P., Canário, J., Lu, J., Holmgren, A., Carvalho, C. Biomarkers of adverse response to mercury: histopathology vs. thioredoxin reductase activity. Journal of Biomedicine and Biotechnology – Special Issue on Mercury Toxicity 2012; doi:10.1155/2012/359879;

Branco, V., Canário, J.,Lu, J. Holmgren, A., Carvalho, C. Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radical Biology and Medicine 2012; 52: 781-793.

Branco, V., Canário, J., Holmgren, A., Carvalho, C. Inhibition of the Thioredoxin System in the Brain and Liver of Zebra-Seabreams Exposed to Waterborne Methylmercury. Toxicology and Applied Pharmacology 2011; 251: 95-103.

Branco, V., Vale, C., Canário, J., Santos, M.N. Mercury and Selenium in blue shark (Prionace glauca, L. 1758) and swordfish (Xiphias gladius, L. 1758) from two areas of the Atlantic Ocean. Environmental Pollution, 2007; 150: 373-380.