PhD (2005) in Pharmacy (Biochemistry), Universidade de Lisboa
Assistant Professor, Biochemistry and Human Biology
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Susana Solá is a major driving force guiding her laboratory stem cell studies. She is dedicated in understanding the molecular mechanisms involved in neural stem cell fate, using both in vitro and in vivo models, and actively identifing potential check points and promising molecules that increase neural stem cell pool and neural differentiation as an alternative of cell death. Recently, she is also interested in exploring the relevance of mitochondrial metabolism in the gut-microbiota-brain interaction to ultimately improve neuroplasticity and neurogenesis in adulthood and ageing.
Soares R, Ribeiro FF, Xapelli S, Genebra T, Ribeiro MF, Sebastião AM, Rodrigues CMP, Solá S. Tauroursodeoxycholic acid enhances mitochondrial biogenesis, neural stem cell pool, and early neurogenesis in adult rats. Mol Neurobiol 2017. [Epub ahead of print].
Morgado AL, Rodrigues CMP, Solá S. MicroRNA-145 regulates neural stem cell differentiation through the Sox2–Lin28/let-7 signaling pathway. Stem Cells 2016; 34: 1386-95.
Morgado AL, Xavier JM, Dionísio PA, Ribeiro MF, Dias RB, Sebastião AM, Solá S, Rodrigues CMP. MicroRNA-34a modulates neural stem cell differentiation by regulating expression of synaptic and autophagic Proteins. Mol Neurobiol 2015; 51:1168-83.
Xavier JM, Morgado AL, Solá S*, Rodrigues CMP*. Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress. Antioxid Redox Signal 2014; 21: 1009-24. *Equally contributed as senior and corresponding authors
Rodrigues CMP, Solá S, Nan Z, Castro RE, Ribeiro PS, Low WC, Steer CJ. Tauroursodeoxycholic acid reduces apoptosis and protects against neurologic injury after acute hemorrhagic stroke in rats. Proc Natl Acad Sci USA 2003; 100: 6087-92.