Susana Dias Lucas
Post Doc Fellow
PhD (2009) in Chemistry (Organic Chemistry), Universidade de Lisboa/F. Hoffmann-La Roche
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
SDLucas is dedicated to the virtual screening and focused structure-based design of Human Neutrophil Elastase inhibitors as a combined approach to boost discovery of drug candidates for the treatment of COPD, namely by the development and validation of molecular docking tools to seek for and optimize new inhibitors with new architectures. The know-how in protease inhibitors and molecular modelling is being applied to the construction of activity-based molecular probes toward therapeutics, target identification and biomarker discovery.
Lucas SD, Gonçalves LM, Afonso LM, Correia HF, Da Costa EMR, Guedes RA, Moreira R, Guedes RC. Optimization of O3-acyl kojic acid derivatives as potent and selective Human Neutrophil Elastase inhibitors. J Med Chem 2013; 56: 9802–9806.
Lucas SD, Costa E, Guedes RC, Moreira R. Targeting COPD: Advances on low-molecular-weight inhibitors of human neutrophil elastase. Med Res Rev 2013; 33: S1, E73–E101.
Lucas SD, Gonçalves LM, Cardote TAF, Correia HF, Moreira R, Guedes RC. Structure Based Virtual Screening for Discovery of Novel Human Neutrophil Elastase Inhibitors. Med Chem Commun 2012; 3: 1299–1304.
Santana AB, Lucas SD, Correia HF, Cardote TAF, Guedes RC, Iley J, Moreira R. N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett 2012; 22: 3993–3997.
Lucas SD, Fischer H, Alker A, Rauter AP, Wessel HP. Libraries on Oxetane δ-Amino Acid Scaffolds: Syntheses and Evaluation of Physicochemical and Metabolic Properties. J Carbohydr Chem 2011; 30: 498-548.