PhD (1991) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Full Professor, Pharmaceutical and Medicinal Chemistry
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Our research is driven by a desire to use chemistry-led approaches to address relevant medical and pharmaceutical questions. We are particularly interested applying our expertise in covalent inhibitors to design activity-based probes to understand the function of enzymes with relevance in infectious diseases, cancer and neurodegenerative disorders. We are also interested in targeted therapies for cancer. Taking advantage of unique metabolic signatures of many tumors, we design prodrugs endowed with tailored mechanisms of activation to selectively deliver cytotoxic payloads inside cancer cells.
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Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque I, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F, Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem 2018; 149: 69-78.
Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, Brites D, Falcão AS. Targeting gliomas: can a new alkylating hybrid compound make a difference? ACS Chem Neurosci 2017; 8: 50-59.
Falcão AS, Carvalho LAR., Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D. Dipeptidyl vinyl sulfone as a novel chemical tool to inhibit HMGB1/NLRP3-inflammasome and inflamma-miRs in Aβ-mediated microglial inflammation’. ACS Chem Neurosci 2017; 8: 89-99.
Ruivo E, Gonçalves L, Carvalho L, Guedes R, Hofbauer S, Brito J, Archer M, Moreira R, Lucas S. Clickable 4-oxo-β-lactam-based probe for human neutrophil elastase related proteomes. Chem Med Chem 2016; 11: 2037-42.
Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. Bis-alkylamine indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem 2014; 57: 3295–3313.