Rui Moreira

PhD (1991) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Full Professor, Pharmaceutical and Medicinal Chemistry

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 477
F (+351) 217 946 470
Researcher ID G-7485-2011
Group Researcher ID B-4834-2014
Scopus Author ID 7102554088

Research Interests

Moreira leads a group that identifies and optimizes small molecules as chemical tools to understand drug targets and their function. Moreira’s research is focused on the discovery of new chemical scaffolds that selectively target enzymes and other proteins involved in inflammation, cancer and infectious diseases. Main achievements of Moreira’s lab include the discovery of highly potent and selective covalent inhibitors of human neutrophil elastase and novel dual-acting antimalarials with the potential to be used in malaria elimination campaigns.

Selected Publications

Lucas SD, Gonçalves LM, Afonso LM, Correia HF, Da Costa EMR., Guedes RA, Moreira R, Guedes RC. Optimization of O3-Acyl Kojic Acid Derivatives as Potent and Selective Human Neutrophil Elastase Inhibitors. J Med Chem 2013; 56: 9802–9806.

Rodrigues T, da Cruz FP, Lafuente-Monasterio M, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira RJ.Quinolon-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem 2013; 56: 4811-4815.

Hanson K, Ressurreição A, Buchholz K, Prudêncio M, Herman-Ornelas JD,Rebelo M, Beatty WL, Wirth DF, Hänscheid T,Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci USA 2013; 110: E2838-E2847.

Lavrado J, Cabal G, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Diaz C, Guedes R, dos Santos D, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of basic side-chains into cryptolepine scaffold. Structure-antimalarial activity relationships and mechanistic studies. J Med Chem 2011; 54: 734-750.

Mulchande J, Oliveira R, Carrasco M, Gouveia L, Guedes RC, Iley J, Moreira R. 4-Oxo--lactams (azetidine-2,4-diones) are potent inhibitors of human leukocyte elastase. J Med Chem 2010; 53: 241-253.