PhD (1991) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Full Professor, Pharmaceutical and Medicinal Chemistry
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Moreira leads a research group on Medicinal Chemistry, covering the development of chemical libraries to generate starting points for drug discovery, the use of computer-aided drug refinement tools to streamline the hit generation process, and the design of tissue- and cell-specific chemical drug delivery systems. Recent achievements of Moreira’s lab include the discovery of multi-stage antimalarial agents and the development of activity-based probes to identify novel drug targets and biomarkers in cancer and inflammation.
Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, Brites D, Falcão AS. Targeting gliomas: can a new alkylating hybrid compound make a difference? ACS Chem Neurosci 2017; 8: 50-59.
Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D. Dipeptidyl vinyl sulfone as a novel chemical tool to inhibit HMGB1/NLRP3-inflammasome and inflamma-miRs in Aβ-mediated microglial inflammation. ACS Chem Neurosci 2017; 8: 89-99.
Ruivo E, Gonçalves L, Carvalho L, Guedes R, Hofbauer S, Brito J, Archer M, Moreira R, Lucas S. Clickable 4-oxo-β-lactam-based probe for human neutrophil elastase related proteomes. ChemMedChem 2016; 11: 2037-42.
Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, dos Santos DJVA, Guedes RC, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. Probing the azaaurone scaffold against the hepatic and erythrocytic stages of malaria parasites. ChemMedChem 2016; 11: 2194-2204.
Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. Bis-alkylamine indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem 2014; 57: 3295–3313.