Rui Fernando Marques da Silva

PhD (2001) in Pharmacy (Cell and Molecular Biology), Universidade de Lisboa
Assistant Professor, Department of Biochemistry and Human Biology

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID G-1910-2011
Group Researcher ID B-5403-2014
Scopus Author ID 36626089100

Research Interests

Main research interests are on the Neurosciences area, in the topics of neurobiology, neurotoxicology, neurodevelopment and glial function associated to neurologic conditions and neurodegeneration. Neuroprotection mechanisms is the most relevant area of intervention, embracing the neuroprotective properties of food natural products and food-borne molecules, either introduced in the regular diet or as additives or medicines, by several cell and molecular mechanisms, beyond the traditional antioxidant properties described for food polyphenols.

Selected Publications

Silva RFM and Pogačnik L. Food, polyphenols and neuroprotection. Neural Regeneration Res 2017; 12: 582-3.

Garcia G, Nanni S, Figueira I, Ivanov I, McDougall GJ, Stewart D, Ferreira RB, Pinto P, Silva RF, Brites D, Santos CN. Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation. Food Chem 2017; 15: 274-83.

Pogačnik L, Pirc K, Palmela I, Skrt M, Kim KS, Brites D, Brito MA, Ulrih NP, Silva RF. Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro. Brain Res 2016; 15: 17-26.

Silva RFM, Rodrigues CMP, Brites D. Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin. Pediatr Res 2002; 51: 535-41.

Silva RFM, Rodrigues CMP, Brites D. Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid. J Hepatol 2001; 3 4: 402-8.