Raquel Frutuoso Machado Frade

Biological Engineering (2002), Instituto Superior Técnico
PhD (2006) in Biology, Universidade de St. Andrews, Scotland
Post.Doc Fellow, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID J-4555-2013
Group Researcher ID B-4209-2014
Scopus Author ID 18037219100

Research Interests

Frade R. F. M. is a Post Doc fellow studying the cytotoxicity and biological activity of new synthetic compounds. Her aim is to identify promising anti-cancer compounds and to pursue their study for elucidation of their mechanisms of action. Compounds are assayed towards human tumor cell lines from colon, breast and lung origin, whereas their cytotoxicity is evaluated in colon adenocarcinoma– caco-2 and non-tumor skin fibroblast cells.

Selected Publications

Frade RFM, Simeonov S, Rosatella AA, Siopa F, Afonso CAM. Toxicological evaluation of magnetic ionic liquids in human cell lines.Chemosphere 2013; 92(1):100-5.
Rosatella AA, Simeonov SP, Frade RFM, Afonso CAM. 5-Hydroxymethylfurfural (HMF) as a Building Block Platform: Biological Properties, Synthesis and Synthetic Applications. Green Chem 2011; 13: 754-93.
Frade RFM, Candeias NR, Duarte CMM, André V, Duarte MT, Góis PMP, Afonso CAM. New dirhodium complex with activity towards colorectal cancer.Bioorg& Med ChemLett 2010;20: 3413-15.
Frade RFM, Rosatella AA, Marques CS, Branco LC, Kulkarni PS, Mateus NMM, Afonso CAM, Duarte CAM. Toxicological evaluation on human colon carcinoma cell line (Caco-2) of ionic liquids based on imidazolium, guanidinium, ammonium, phosphonium, pyridinium and pyrrolidiniumcations. Green Chem 2009; 11:1660-65.
Makiyi EF, Frade RFM, Lebl T, Jaffray E, Cobb SE, Harvey AL, Slawin AMZ, Hay TH, Westwood NJ. Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation. Eur J Org Chem2009; 33:5711-15.