Pedro M. P. Gois
PhD (2005) in Organic Chemistry, Universidade Nova de Lisboa
Post-Doctoral research at Sussex University; University College of London; IST
Assistant professor with habilitation, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
The research conducted at Gois’ laboratory spans over the interface of organic chemistry and biology, aiming at the discovery of new generic synthetic methods and chemical probes that may be further explored to tackle important biological problems. We are currently focusing on the:
- Synthesis of functional boron containing compounds and their evaluation as modulators of specific proteins.
- Development of generic synthetic methods to modified proteins and their use in the synthesis of “smart” bioconjugates.
- Development of synthetic methodologies for the preparation of small molecule modulators of enzymes and proteins identified as key therapeutic targets and cytotoxic agents.
Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, Gois PMP. Modular Assembly of Reversible Multivalent Targeting Drug Conjugates. Angew. Chem. Int. Ed. 2017, 56, 9346-9350.
Faustino H, Silva MJSA, Veiros LF, Bernardes GJL, Gois PMP. “Iminoboronates are Efficient Intermediates for Selective, Rapid and Reversible N-Terminal Cysteine Functionalisation” Chem. Sci. 2016, 7, 5052-5058.
Santos FMF, Rosa JN, Candeias NR, Carvalho CP, Matos AI, Ventura AE, Florindo HF, Silva LC, Pischel U, Gois PMP. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes). Chem. Eur. J. 2016, 5, 1631-1637 (VIP paper and cover).
Cal PMSD, Cordeiro C, Gois PMP. Reversible Lysine Modification on Proteins using Functionalized Boronic Acids. Chem. Eur. J. 2015, 21, 8182-8187.
Cal PMSD, Vicente JB, Pires E, Coelho AV, Veiros LF, Cordeiro C, Gois PMP. Iminoboronates: A New Strategy for Reversible Protein Modification. J. Am. Chem. Soc. 2012, 134, 10299.