Nuno Guerreiro Oliveira
PhD (2003) in Pharmacy (Toxicology), Universidade de Lisboa (UL)
MSc (1998) in Food Quality Control and Toxicology, Faculdade de Farmácia, UL
Degree in Pharmaceutical Sciences (1993), Faculdade de Farmácia, UL
Assistant Professor at Faculdade de Farmácia, UL (since 2003)
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Nuno Oliveira has been interested in Genetic Toxicology and its impact in cancer research. He has been studying the mechanisms of DNA damage and repair induced by chemotherapeutic drugs (e.g. doxorubicin, oxaliplatin, MMC), food mutagens (e.g. acrylamide) as well as by Ionizing radiation and radiomimetic compounds. He is currently interested in the study of in vitro approaches towards breast cancer therapy using superoxide dismutase mimics (SODm) and DNA repair inhibitors (e.g. APE1 inhibitors).
Costa JG, Saraiva N, Guerreiro PS, Louro H, Silva MJ, Miranda JP, Castro M, Batinic-Haberle I, Fernandes AS, Oliveira NG. Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. Food Chem Toxicol. 2016 87: 65–76.
Guerreiro PS, Corvacho E, Costa JG, Saraiva N, Fernandes AS, Castro M, Miranda JP, Oliveira NG. The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel. Chem Biol Drug Des. 2017. doi: 10.1111/cbdd.12979.
Fernandes AS, Saraiva N, Oliveira NG. Redox therapeutics in breast cancer: role of SOD mimics, in Redox-active therapeutics (Rebouças JS, Batinic-Haberle I, Spasajevic I, Warner DS, Clair D, eds). Springer-Verlag, US. 2016. Chapter 18, pp. 451-467.
Ramos DL, Gaspar JF, Pingarilho M, Gil OM, Fernandes AS, Rueff J, Oliveira NG. Genotoxic effects of doxorubicin in cultured human lymphocytes with different glutathione S-transferase genotypes. Mutat Res. 2011; 724: 28–34.
Martins C*, Oliveira NG*, Pingarilho M, Gamboa da Costa G, Martins V, Marques MM, Beland FA, Churchwell MI, Doerge DR, Rueff J, Gaspar, JF. Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts. Toxicol Sci. 2007; 95: 383–390.