Nuno Guerreiro Oliveira
PhD (2003) in Pharmacy (Toxicology), Universidade de Lisboa (UL)
MSc (1998) in Food Quality Control and Toxicology, Faculdade de Farmácia, UL
Degree in Pharmaceutical Sciences (1993), Faculdade de Farmácia, UL
Assistant Professor at Faculdade de Farmácia, UL (since 2003)
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Nuno Oliveira has been interested in Genetic Toxicology and its impact in cancer research. He has been studying the mechanisms of DNA damage and repair induced by chemotherapeutic drugs (e.g. doxorubicin, oxaliplatin, MMC), food mutagens (e.g. acrylamide) as well as by Ionizing radiation and radiomimetic compounds. He is currently interested in the study of in vitro approaches towards breast cancer therapy using superoxide dismutase mimics (SODm) and DNA repair inhibitors (e.g. APE1 inhibitors).
Fernandes AS, Costa J, Gaspar J, Rueff J, Cabral MF, Cipriano M, Castro M, Oliveira NG. Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells. Free Radic Res 2012; 46: 1157-66.
Ramos DL, Gaspar JF, Pingarilho M, Gil OM, Fernandes AS, Rueff J, Oliveira NG. Genotoxic effects of doxorubicin in cultured human lymphocytes with different glutathione S-transferase genotypes. Mutat Res 2011; 724: 28–34.
Fernandes AS, Gaspar J, Cabral MF, Caneiras C, Guedes R, Rueff J, Castro M, Costa J, Oliveira NG. Macrocyclic copper(II) complexes: superoxide scavenging activity, structural studies and cytotoxicity evaluation. J Inorg Biochem 2007; 101: 849-858.
Martins C*, Oliveira NG*, Pingarilho M, Gamboa da Costa G, Martins V, Marques MM, Beland FA, Churchwell MI, Doerge DR, Rueff J, Gaspar, JF. Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts. Toxicol Sci 2007; 95: 383-90.
Gil OM, Oliveira NG, Rodrigues AS, Laires A, Ferreira TC, Limbert E, Rueff J. Possible transient adaptive response to mitomycin C in peripheral lymphocytes from thyroid cancer patients after iodine-131 therapy. Int J Cancer 2002; 102: 556-61.