Noélia Maria da Silva Dias Duarte
PhD (2008) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor, Department of Toxicological and Bromatological Sciences
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
N. Duarte research work has been focus on the isolation and structural characterization of novel bioactive chemical scaffolds from plants. In particular, she has been actively involved in the optimization of macrocyclic diterpenes as lead compounds for the development of P-gp modulators and search of antineoplastic agents, targeting multidrug resistant cancer cells. Duarte is been also interested in the isolation of compounds with antibacterial, anti-tuberculosis and antimalarial activities.
Nim S, Mónico A, Rawalb M K, Duarte N, Prasad R, Di Pietro A, Ferreira MJU. Overcoming multidrug resistance in Candida albicans: macrocyclic diterpenes from Euphorbia species as potent inhibitors of drug-efflux pumps. Planta Med 2016; 82: 1180-5.
Matos AM, Reis M, Duarte N, Spengler G, Molnár J, Ferreira MJU. Epoxylathyrol derivatives: modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-lymphoma cells. J Nat Prod 2015; 78: 2215-28.
Vieira C, Duarte N, Reis M, Spengler G, Madureira AM, Molnár J, Ferreira MJU. Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes. Bioorg Med Chem 2014; 22: 6392-400.
Ferreira MJ, Duarte N, Reis M, Madureira AM, Molnár J. Euphorbia and Momordica metabolites for overcoming multidrug resistance. Phytochem Rev 2014; 13: 915-35.
Luo X, Pires D, Ainsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJ. Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages. J Ethnopharmacol 2013; 146: 417-22.