Ph. D (2013) in Synthetic Organic Chemistry,
Central Drug Research Institute, Lucknow, India.
Post Doc Fellow
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Current Reserach is the design and executing multi-step and target oriented synthesis of range of novel heterocyclic small molecules. I have focused on the multicomponent reaction that provides highly substituted bioactive prototypes in a very short synthetic sequence with a strong emphasis on drug-design. Study of the structure-activity relationships (SAR) and the selection of optimized leads for in vivo assays, based on in vitro screening and metabolic profiles
Sharma M, Chauhan K, Shivahare R, Vishwakarma P, Suthar MK, Sharma A. Gupta S, Saxena JK, Lal J, Chandra P, Kumar B, Chauhan PMS. Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents. J. Med. Chem. 2013, 56, 4374.
Sharma M, Pandey S, Chauhan K, Sharma D, Kumar B, Chauhan PMS. Cyanuric Chloride Catalyzed Mild Protocol for Synthesis of Biologically Active Dihydro/Spiro Quinazolinones and Quinazolinone-glycoconjugates. J. Org. chem. 2012, 77, 929.
Sharma M, Chaturvedi V, Manju YK, Bhatnagar S, Srivastava K, Puri, SK, Chauhan PMS. Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents. Eur J. Med. Chem. 2009, 44, 2081.
Sharma M, Chauhan K, Chauhan S, Kumar A, Singh SV, Saxena JK, Agarwal P, Srivastava K, Kumar SR, Puri SK, Shah P, Siddiqi MI, Chauhan, PMS. Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as Plasmodium falciparum transketolase and β-hematin inhibitors. Med. Chem. Commun. 2012, 3, 71.
Sharma M, Mahar R, Shukla SK, kant R, Chauhan PMS. Potassium carbonate mediated unusual transformation of biologically active 2,3-dihydroquinazolinone via Cascade reaction. Tetrahedron lett. 2013, 54, 6171-6177.