Matilde Fonseca e Castro

Habilition in Chemistry Group (2002), Universidade de Lisboa.
PhD (1989) in Pharmacy (Pharmaceutical  Chemistry), Universidade de Lisboa.
Full Professor, Pharmaceutical Chemistry and Analytical Chemistry, since 2005.
Dean of Faculdade Farmácia Universidade Lisboa, since 2012.

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 460
F (+351) 217 946 470
Researcher ID A-9468-2014
Group Researcher ID B-4215-2014
Scopus Author ID 7402291360

Research Interests

Has been interested in mechanisms associated with interactions between chemicals and biological systems. In particular, the research work is focused on: a) the development of 3D cell cultures for toxicological and cell therapy studies, b) the development of novel macrocyclic compounds, namely catalytical antioxidants (superoxide dismutase mimetics) and anti-angiogenic agents (Cu(II) chelators); c) biocompatibility studies of acrylic and ceramic based biomaterials.

Selected Publications

Bettencourt A, Calado ART, Amaral J, Vale F, Toscano Rico J M, Monteiro J, Montemor MF, Ferreira MGS, Castro M. (2004). Surface studies on acrylic bone cements. Int J Pharmaceutics; 278: 181-186.

Gonçalves S, Fernandes AS, Oliveira NG*, Marques J, Costa J, Fátima Cabral M, Miranda J, Cipriano M, Guerreiro PS, Castro M. (2012). Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of the macrocycle [15]pyN(5). Food Chem Toxicol; 5021, 80-87.

Fernandes AS, Gaspar J, Cabral MF, Caneiras C, Guedes R, Rueff J, Castro M, Costa J, Oliveira NG (2007). Macrocyclic copper(II) complexes: superoxide scavenging activity, structural studies and citotoxicity evaluation.  J Inorg Biochem; 101, 849-858.

Fernandes AS, Gaspar J, Cabral MF, Rueff J, Castro M, Batinic-Haberle I, Costa J, Oliveira NG. (2010). Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide. Free Radic Res; 44,  430-440.

Fernandes AS, Costa J, Gaspar J, Rueff J, Cabral MF, Cipriano M, Castro M, Oliveira NG. Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells. (2012). Free Radic Res; 46: 1157-66.