Maria M. M. Santos

PhD (2004) in Chemistry (Organic Synthesis), Universidade Nova de Lisboa
Post Doc Researcher at University of Barcelona (2004-2006)
Post Doc Researcher at University of Lisbon (2006-2008)
Ciência 2007 (2008-2013)
Investigador FCT 2013 (2013-present)

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 451
F (+351) 217 946 470
Researcher ID I-7189-2013
Group Researcher ID B-4834-2014
Scopus Author ID 8634544500

Research Interests

Santos has an established research group of medicinal chemistry and several ongoing funded projects. The ultimate goal of her basic research is the development of general synthetic methods and strategies, and their application to the synthesis of bioactive molecules.Main achievements of Santos’s lab include the discovery of highly potent and selective MDM2-p53 interaction inhibitors and other apoptosis modulators.

Selected Publications

Pereira NAL, Monteiro A, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R, Rosenthal PJ, Prudêncio M, Santos MMM. Enantiopure Indolizinoindolones with In Vitro Efficiency against Blood- and Liver-Stage Malaria Parasites. ChemMedChem 2015; 10: 2080-2089.

Soares J, Raimundo L, Pereira NAL, Monteiro A, Gomes S, Bessa C, Pereira C, Queiroz G, Bisio A, Fernandes J, Gomes C, Reis F, Gonçalves J, Inga A, Santos MMM, Saraiva L. Reactivation of wild-type and mutant p53 by tryptophanol-derived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget 2016 (in press).

Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Spirooxadiazoline oxindoles with promising in vitro antitumor activities. Med Chem Commun (“New Talent: Europe” issue) 2016 (in press).

Santos DM, Santos MMM, Moreira R, Solá S, Rodrigues CMP. Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural SteCell Differentiation by Regulating Redox State. Mol Neurobiol 2013; 47: 313-324.

Amat M, Ramos C, Pérez M, Molins E, Florindo P, Santos MMM, Bosch J. Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline. Chem Commun 2013, 49: 1954-1956.