Maria L. Corvo
PhD (1998) in Pharmaceutical Sciences, Utrecht University, NL
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Corvo has been working on the development of drug carrier systems for the delivery anti-inflammatory drugs. Systems developed were liposomes (attractive delivery systems) for the treatment of Rheumatoid Arthritis and different type of nanoparticles, SOD Enzymosomes, to treat and visualize Ischaemia/Reperfusion Injury (following organ transplantation). Corvo has also been studying mechanisms of action of developed formulation and their correlation with biomarkers, tissue disposition and pharmacokinetics.
Marcelino P, Marinho HS, Campos MC, Neves AR, Real C, Fontes FS, Carvalho A, Feio G, Martins MBF, Corvo ML. Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy. Eur.J Pharm Sci 2017; 109: 464-471.
Fernandes AR, Jesus J, Martins P, Figueiredo S, Rosa D, Martins LM, Corvo ML, Carvalheiro MC, Costa PM, Baptista PV. Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. Journal of Controlled Release 2017; 245: 52-61.
Duarte I, Corvo ML, Serodio P, Vicente J, Pinto JF, Temtem M. Production of Nano-Solid Dispersions Using a Novel Solvent-Controlled Precipitation Process – Benchmarking Their in Vivo Performance With an Amorphous Micro-Sized Solid Dispersion Produced by Spray Drying. Eur J Pharm Sci 2016; 93: 203-214
Corvo ML, Marinho HS, Marcelino P, Lopes R, Vale CA, Marques C, Martins LCD, Fontes F, Laverman P, Storm G, Martins MBF. Superoxide dismutase enzymosomes: carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm Res 2015; 32: 91102.
Martins MBF, Corvo ML, Marcelino P, Marinho HS, Feio G, Carvalho A. New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI. Nanomedicine: Nanotechnology, Biology and Medicine 2014; 10: 207-14.