Maria José Umbelino Ferreira

PhD (1990) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa

Associate Professor with Habilitation, Pharmaceutical and Medicinal Chemistry, FFULisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 475
F (+351) 217 946 470
Researcher ID M-8053-2013
Group Researcher ID B-5387-2014
Scopus Author ID 7402787141

Research Interests

MJU Ferreira leads the group of Natural Products Chemistry. Her main interest is the search for bioactive compounds from plants. She is focused on two research areas: cancer and infectious diseases. Particularly, her main goal is to discover anticancer compounds, with emphasis on targeting multidrug-resistant cancer cells, namely P-glycoprotein modulators, apoptosis inducers and selective antineoplastic compounds. The development of anti-infective molecules from African medicinal plants, used in traditional medicine, is also one of her goals.

Selected Publications

Paterna A, Kincses A, Spengler G, Mulhovo S, Molnár J, Ferreira MJU. Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells. Eur J Med Chem 2017; 128:247-257.

Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira MJU. Exploring jolkinol D derivatives to overcome multidrug resistance in cancer. J Nat Prod 2017; 80: 1411-1420.

Pereira F, Madureira AM, Sancha S, Mulhovo S, Luo X, Duarte A, Ferreira MUJ. Cleistochlamys kirkii chemical constituents: antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains. J Ethnopharmacol 2016; 178: 180-187.

Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CM, Ferreira MJU. Vobasinyl-Iboga alkaloids from Tabernaemontana elegans: cell cycle arrest and apoptosis-inducing activity in HCT116 colon cancer cells. J Nat Prod 2016; 79: 2624-2634.

Rocha E Silva LF, Ramalhete C, Nogueira KL, Mulhovo S, Ferreira MUJ, Pohlit AM. In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents. Eur J Med Chem 2015; 102: 398-402.