Maria J. Nunes
PhD (2012) in Pharmacy (Molecular and Cellular Biology), Universidade de Lisboa
Post-Doctoral Fellow, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Maria Nunes’ interests concern the relevance of epigenetic mechanisms in the context of neurodegeneration. Her work is focused on the role of histone deacetylases in brain cholesterol metabolism, with the goal of defining HDAC inhibition as a potential therapeutic tool on neurodegenerative conditions with impaired cholesterol metabolism. Moreover, the identification of transcriptional co-factors that participate in the regulation of brain cholesterol homeostasis is also part of her post-doctoral project.
Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Ruas JL and Rodrigues E. Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk. Sci Rep 2016; 6: 30928.
Nunes MJ, Moutinho M, Gama MJ, Rodrigues CMP and Rodrigues, E. Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. PLoS One 2013; 8: e53394.
Nunes MJ, Moutinho M, Milagre I, Gama MJ and Rodrigues E. Okadaic acid inhibits the TSA-mediated increase of human CYP46A1 expression in a Sp3-ERK1/2-dependent pathway. J Lipid Res 2012; 53: 1910-9.
Milagre I*, Nunes MJ*, Castro-Caldas M, Moutinho M, Gama MJ and Rodrigues E. Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter. J Neurochem 2012; 120: 220-9.
*Both authors equally contributed to this work
Nunes MJ, Milagre I, Schnekenburger M, Gama MJ, Diederich M and Rodrigues E. Sp proteins play a critial role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription. J Neurochem 2010; 113: 418-31.