Maria João Carlos da Silva Gama
PhD (2001) in Pharmacy (Molecular Biology and Genetics), Universidade de Lisboa
Assistant Professor, Biochemistry and Human Biology
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Maria João primary research interests focuses on the role of drug metabolizing enzymes in neurodegenerative diseases, namely Parkinson’s disease. Studies were undertaken to assess the impact of genetic diversity and polymorphism of phase II drug metabolizing enzyme genes developed into risk assessment in neurodegenerative diseases. The main goal of ongoing studies is to further characterize the neuronal protective role of Glutathione S-Transferase pi against dopaminergic cell death using the MPTP Parkinson’s disease mouse model.
Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, van Horsen J, Gama MJ. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett 2016; 590: 1455-66.
Neves Carvalho A, Marques C, Rodrigues E, Henderson CJ, Wolf CR, Pereira P, Gama MJ. Ubiquitin–Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice. Mol Neurobiol 2013; 47: 662-72.
Castro-Caldas M, Neves Carvalho A, Rodrigues E, Henderson CJ, Wolf CR, Rodrigues CMP, Gama MJ. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson’s disease. Mol Neurobiol 2012; 46: 475-86.
Castro-Caldas M, Neves Carvalho A, Rodrigues E, Henderson CJ, Wolf CR, Gama MJ. Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway. Mol Neurobiol 2012; 45: 466-77.
Castro-Caldas M, Carvalho AN, Peixeiro I, Rodrigues E, Lechner MC, Gama MJ. Gst pi expression and MPTP- induced dopaminergic neurodegeneration in C57BL/6 mouse midbrain and striatum. J Mol Neurosci 2009; 38: 114-27.