Maria Henriques Lourenço Ribeiro

PhD (1994) in Pharmacy (Pharmaceutical Chemistry, Biotechnology), Universidade de Lisboa
Associate Professor, Therapeutics and Pharmaceutical Biotechnology

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID A-5993-2008
Group Researcher ID B-4215-2014
Scopus Author ID 7201715065

Research Interests

Maria H Ribeiro leads investigation in the Biotechnology and Bioengineering area, on the design and development of biotech compounds (e.g. small-molecules and proteins) towards biotechnology-derived therapeutics, against disease, as cancer and neurodegenerative. Her focus is based on rational strategies of: i) enzyme and cell-based culture biosystems with process intensification through miniaturization to downstream processing; ii) biocatalysts performance improvement (e.g. hydrolases) in non-conventional (e.g. immobilization) and high-pressure systems; iii) tailoring (bio)responsive polymeric biomaterials networks (e.g. hydrogels, encapsulation, electrospining); iv) innovative bioconversions, like (de)glycosylations (e.g. glycosides and peptides), biosurfactants production (glycolipids and lipoamino acids) to be used as drug delivery and transfection agents.

Selected Publications

Nunes MAP, Fernandes PCB, Ribeiro MHL. Microtiter plates versus stirred mini-bioreactors in biocatalysis: A scalable approach.  Bioresource Technol 2013; 136, 30-40.

Ribeiro, I.A., Bronze, M.R., Castro, M.F., Ribeiro, M.H.L. Sophorolipids: improvement of the selective production by Starmerella bombicola through the design of nutritional requirements. Appl Microbiol Biotechnol 2013; 1-13.

Vila-Real H, Alfaia AJI, Rosa JN, Gois PMP, Rosa ME, Calado ART, Ribeiro MHL. alfa-Rhamnosidase and beta-glucosidase expressed by naringinase immobilized within new ionic liquid sol-gel matrices: activity and stability studies. J Biotechnol 2011; 4: 147-158.

Ribeiro IA, Rocha J, Sepodes B, Mota-Filipe H, Ribeiro MHL. Effect of naringin enzymatic hydrolysis towards naringenin on the anti-inflammatory activity of both compounds. J Mol Catal B Enzym. 2008; 52-53: 13-18.

Pedro HA, Alfaia AJ, Marques J, Vila-Real HJ, Calado AT, Ribeiro MHL. Design of an immobilized enzyme system for naringin hydrolysis at high pressure. Enz Microbiol Technol 2007; 40: 442-446.